Meyer, Mandy and Hoels, Ann-Kathrin and Liersch, Britta and Leistner, Rasmus and Gellert, Klaus and Schalke, Berthold and Marx, Alexander and Niedobitek, Gerald (2011) Lack of Evidence for Epstein-Barr Virus Infection in Myasthenia Gravis Thymus. ANNALS OF NEUROLOGY, 70 (3). pp. 515-518. ISSN 0364-5134, 1531-8249
Full text not available from this repository. (Request a copy)Abstract
A role for Epstein-Barr virus (EBV) in myasthenia gravis pathogenesis has been suggested recently. Using in situ hybridization for the detection of the EBV-encoded RNAs and EBNA1-specific immunohistochemistry, we found no latently infected cells in a series of thymus specimens from patients with myasthenia gravis showing lymphofollicular thymitis. In addition, using immunohistochemistry and an antibody specific for the viral immediate early protein BZLF1, no evidence of lytic EBV infection was seen in these cases. Our results therefore do not support a direct role of thymic EBV infection in the pathogenesis of myasthenia gravis. ANN NEUROL 2011;70:515-518
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MULTIPLE-SCLEROSIS BRAIN; SYSTEMIC-LUPUS-ERYTHEMATOSUS; RHEUMATOID-ARTHRITIS; EPITHELIAL-CELLS; VIRAL-INFECTION; EBV INFECTION; MONONUCLEOSIS; REPLICATION; PERSISTENCE; ANTIBODIES; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Jun 2020 06:24 |
| Last Modified: | 02 Jun 2020 06:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20305 |
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