Maringwa, John T. and Quinten, C. and King, M. and Ringash, J. and Osoba, D. and Coens, C. and Martinelli, F. and Reeve, B. B. and Gotay, C. and Greimel, E. and Flechtner, H. and Cleeland, C. S. and Schmucker-Von Koch, J. and Weis, J. and Van Den Bent, M. J. and Stupp, R. and Taphoorn, M. J. and Bottomley, A. (2011) Minimal clinically meaningful differences for the EORTC QLQ-C30 and EORTC QLQ-BN20 scales in brain cancer patients. ANNALS OF ONCOLOGY, 22 (9). pp. 2107-2112. ISSN 0923-7534,
Full text not available from this repository. (Request a copy)Abstract
Background: We aimed to determine the smallest changes in health-related quality of life (HRQoL) scores in the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire core 30 and the Brain Cancer Module (QLQ-BN20), which could be considered as clinically meaningful in brain cancer patients. Materials and methods: World Health Organisation performance status (PS) and mini-mental state examination (MMSE) were used as clinical anchors appropriate to related subscales to determine the minimal clinically important differences (MCIDs) in HRQoL change scores (range 0-100) in the QLQ-C30 and QLQ-BN20. A threshold of 0.2 standard deviation (SD) (small effect) was used to exclude anchor-based MCID estimates considered too small to inform interpretation. Results: Based on PS, our findings support the following integer estimates of the MCID for improvement and deterioration, respectively: physical (6, 9), role (14, 12), and cognitive functioning (8, 8); global health status (7, 4(star)), fatigue (12, 9), and motor dysfunction (4(star), 5). Anchoring with MMSE, cognitive functioning MCID estimates for improvement and deterioration were (11, 2(star)) and for communication deficit were (9, 7). Estimates with asterisks were <0.2 SD and were excluded from our MCID range of 5-14. Conclusion: These estimates can help clinicians evaluate changes in HRQoL over time, assess the value of a health care intervention and can be useful in determining sample sizes in designing future clinical trials.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | QUALITY-OF-LIFE; MENTAL-STATE-EXAMINATION; HEALTH-STATUS MEASURES; EUROPEAN-ORGANIZATION; STANDARD-DEVIATION; REPORTED OUTCOMES; PHASE-III; QUESTIONNAIRE; SCORES; UNIVERSALITY; anchoring; deterioration; EORTC QLQ-C30; health-related quality of life; improvement; minimal clinically important difference |
| Subjects: | 100 Philosophy & psychology > 100 Philosophy |
| Divisions: | Philosophy, Art History, History, and Humanities > Institut für Philosophie > Alumni or Retired Professors > Prof. Dr. phil. habil. Joseph F. Schmucker-von Koch |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Jun 2020 09:50 |
| Last Modified: | 02 Jun 2020 09:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20316 |
Actions (login required)
 |
View Item |
