Jitschin, R. and Peters, O. and Plentz, A. and Turowski, P. and Segerer, H. and Modrow, S. (2011) Impact of parvovirus B19 infection on paediatric patients with haematological and/or oncological disorders. CLINICAL MICROBIOLOGY AND INFECTION, 17 (9). pp. 1336-1342. ISSN 1198-743X, 1469-0691
Full text not available from this repository. (Request a copy)Abstract
To determine the frequency and the impact of parvovirus B19 (B19V) infection and its influence on the course of haematological and/or oncological diseases in paediatric patients, consecutive serum and bone marrow samples from 110 were analyzed for markers of acute, past and persistent B19V-infection using qPCR, ELISA and WesternLine. Twenty-seven out of 110 (24.5%) children suffered from nonmalignant diseases (anaemia, pancytopenia, autoimmune disorders); 68/110 (61.8%) patients had developed leukaemia, malignant lymphoma or solid malignant tumours; 15/110 patients (13.6%) presented with other symptoms. At admission, B19V-specific IgM and IgG indicating acute or previous B19V-infection were observed in 5 (4.5%) and 48 patients (43.6%), respectively. B19V-DNA (10(3) -10(9) geq/mL) was detectable in serum and/or bone marrow of 22 patients (20.0%). These suffered from leukaemia (5), non-Hodgkin lymphoma (2), solid tumours (6), autoimmune (4) and haematological (4) disease and fever (1). During clinical observation four further leukaemia patients developed viraemia and persistent B19V-infection was observed in 13/22 DNA-positive patients. Treatment of B19V-DNA-positive cancer patients was associated with more supportive therapy involving erythrocyte and thrombocyte transfusion and/or antibiotic therapy. Acute B19V-infection has been frequently observed in paediatric patients with haematological and/or oncological disease. In patients with non-malignant diseases anaemia or autoimmune disorders were diagnosed in association with B19V-infection. Furthermore, a significant number of cancer patients displayed markers for acute, recent or persistent B19V-infection. This association may be strengthened by frequent treatment with blood products combined with therapeutic immune suppression. In B19V-infected cancer patients supportive therapy was more complex.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACUTE-LYMPHOBLASTIC-LEUKEMIA; IDIOPATHIC THROMBOCYTOPENIC PURPURA; NONSTRUCTURAL PROTEIN; APLASTIC CRISIS; ARTHRITIS; CHILDREN; ANTIBODIES; DISEASE; PATHOGENESIS; ASSOCIATION; Haematological disease; leukaemia; oncological disease; parvovirus B19; persistence |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Jun 2020 06:39 |
| Last Modified: | 02 Jun 2020 06:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20333 |
Actions (login required)
 |
View Item |
