Wanninger, Josef and Weigert, Johanna and Wiest, Reiner and Bauer, Sabrina and Karrasch, Thomas and Farkas, Stefan and Scherer, Marcus N. and Walter, Roland and Weiss, Thomas S. and Hellerbrand, Claus and Neumeier, Markus and Schaeffler, Andreas and Buechler, Christa (2011) Systemic and hepatic vein galectin-3 are increased in patients with alcoholic liver cirrhosis and negatively correlate with liver function. CYTOKINE, 55 (3). pp. 435-440. ISSN 1043-4666,
Full text not available from this repository. (Request a copy)Abstract
Recently we demonstrated higher galectin-3 in portal venous serum (PVS) compared to hepatic venous serum (HVS) in a small cohort of patients with normal liver function suggesting hepatic removal of galectin-3. Here, galectin-3 was measured by ELISA in PVS, HVS and systemic venous blood (SVS) of 33 patients with alcoholic liver cirrhosis and a larger cohort of 11 patients with normal liver function. Galectin-3 was cleared by the healthy but not the cirrhotic liver, and subsequently HVS and SVS galectin-3 levels were significantly increased in the patients with liver cirrhosis compared to controls. In healthy liver galectin-3 was produced by cholangiocytes and synthesis by hepatocytes was only observed in cirrhotic liver. Hepatic venous pressure gradient did not correlate with galectin-3 levels excluding hepatic shunting as the principal cause of higher SVS galectin-3. Galectin-3 was elevated in all blood compartments of patients with CHILD-PUGH stage C compared to patients with CHILD-PUGH stage A, and was higher in patients with ascites than patients without this complication. Galectin-3 was negatively associated with antithrombin-3 whose synthesis is reduced with worse liver function. Galectin-3 positively correlated with urea and creatinine, and PVS galectin-3 showed a negative association with creatinine clearance as an accepted measure of kidney function. To summarize in the current study systemic, portal and hepatic levels of galectin-3 were found to be negatively associated with liver function in patients with alcoholic liver cirrhosis and this may in part be related to impaired hepatic removal and/or increased synthesis in cirrhotic liver. (c) 2011 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEPATOCELLULAR-CARCINOMA; HEPATORENAL-SYNDROME; BINDING-PROTEIN; CANCER-PATIENTS; KNOCKOUT MICE; AGE-RECEPTOR; ACTIVATION; EXPRESSION; INFLAMMATION; PROGNOSIS; Galectin-3; Liver cirrhosis; Hepatic vein; Portal vein |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Jun 2020 09:55 |
| Last Modified: | 02 Jun 2020 09:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20334 |
Actions (login required)
 |
View Item |
