Hutchinson, James A. and Riquelme, Paloma and Sawitzki, Birgit and Tomiuk, Stefan and Miqueu, Patrick and Zuhayra, Maaz and Oberg, Hans H. and Pascher, Andreas and Luetzen, Ulf and Janssen, Uwe and Broichhausen, Christiane and Renders, Lutz and Thaiss, Friedrich and Scheuermann, Ernst and Henze, Eberhard and Volk, Hans-Dieter and Chatenoud, Lucienne and Lechler, Robert I. and Wood, Kathryn J. and Kabelitz, Dieter and Schlitt, Hans J. and Geissler, Edward K. and Faendrich, Fred (2011) Cutting Edge: Immunological Consequences and Trafficking of Human Regulatory Macrophages Administered to Renal Transplant Recipients. JOURNAL OF IMMUNOLOGY, 187 (5). pp. 2072-2078. ISSN 0022-1767,
Full text not available from this repository. (Request a copy)Abstract
Regulatory macrophages (M regs) were administered to two living-donor renal transplant recipients. Both patients were minimized to low-dose tacrolimus monotherapy within 24 wk of transplantation and subsequently maintained excellent graft function. After central venous administration, most M regs remained viable and were seen to traffic from the pulmonary vasculature via the blood to liver, spleen, and bone marrow. By 1 y posttransplantation, both patients displayed patterns of peripheral blood gene expression converging upon the IOT-RISET signature. Furthermore, both patients maintained levels of peripheral blood FOXP3 and TOAG-1 mRNA expression within the range consistent with nonrejection. It is concluded that M regs warrant further study as a potential immune-conditioning therapy for use in solid-organ transplantation. The results of this work are being used to inform the design of The ONE Study, a multinational clinical trial of immuno-modulatory cell therapy in renal transplantation. The Journal of Immunology, 2011, 187: 2072-2078.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACCEPTANCE-INDUCING-CELLS; TACROLIMUS MONOTHERAPY; IMMUNOSUPPRESSION; PRETREATMENT; ACTIVATION; REJECTION; TOLERANCE; DRIVEN; STATE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Jun 2020 11:46 |
| Last Modified: | 02 Jun 2020 11:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20351 |
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