Quera-Salva, Maria-Antonia and Hajak, Goeran and Philip, Pierre and Montplaisir, Jaques and Keufer-Le Gall, Sophie and Laredo, Judith and Guilleminault, Christian (2011) Comparison of agomelatine and escitalopram on nighttime sleep and daytime condition and efficacy in major depressive disorder patients. INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 26 (5). pp. 252-262. ISSN 0268-1315,
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Agomelatine, an MT(1)/MT(2) receptor agonist and 5-HT(2C) receptor antagonist antidepressant, is known to have beneficial effects on subjective sleep in major depressive disorder patients. This international multicenter, randomized, double-blind study compared the effects of agomelatine (25-50 mg/day) and escitalopram (10-20 mg/day) on sleep polysomnographic parameters in major depressive disorder patients treated up to 24 weeks. A total of 138 outpatients were randomly allocated to agomelatine (n = 71) or escitalopram (n = 67). Treatment with agomelatine was associated with a reduction in sleep latency from week 2 onward. The difference between treatments was significant on all evaluations. Rapid eye movement latency was increased with escitalopram compared with agomelatine, with significant between-group differences at every visit. Agomelatine preserved the number of sleep cycles, whereas it was decreased with escitalopram with significant between group differences at every visit. Assessments on visual analogue scales indicated that treatment with agomelatine improved morning condition, and reduced daytime sleepiness compared with escitalopram. 17-item Hamilton depression rating scale total score was reduced in both groups, agomelatine was statistically noninferior to escitalopram at 6 weeks. Both treatments were well tolerated. This study showed that the clinical effects of agomelatine on sleep and wake parameters are different from that of escitalopram. Int Clin Psychopharmacol 26:252-262 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MELATONIN AGONIST; ANTIDEPRESSANTS; MIRTAZAPINE; S-20098; PLACEBO; PERFORMANCE; SYMPTOMS; INSOMNIA; RHYTHMS; TRIAL; agomelatine; antidepressant; escitalopram; polysomnography; sleep |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Jun 2020 07:57 |
| Last Modified: | 02 Jun 2020 07:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20363 |
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