Ellis, Sarah L. and Grassinger, Jochen and Jones, Allan and Borg, Judy and Camenisch, Todd and Haylock, David and Bertoncello, Ivan and Nilsson, Susan K. (2011) The relationship between bone, hemopoietic stem cells, and vasculature. BLOOD, 118 (6). pp. 1516-1524. ISSN 0006-4971,
Full text not available from this repository. (Request a copy)Abstract
A large body of evidence suggests hemopoietic stem cells (HSCs) exist in an endosteal niche close to bone, whereas others suggest that the HSC niche is intimately associated with vasculature. In this study, we show that transplanted hemopoietic stem and progenitor cells (HSPCs) home preferentially to the trabecular-rich metaphysis of the femurs in nonablated mice at all time points from 15 minutes to 15 hours after transplantation. Within this region, they exist in an endosteal niche in close association with blood vessels. The preferential homing of HSPCs to the metaphysis occurs rapidly after transplantation, suggesting that blood vessels within this region may express a unique repertoire of endothelial adhesive molecules. One candidate is hyaluronan (HA), which is highly expressed on the blood vessel endothelium in the metaphysis. Analysis of the early stages of homing and the spatial distribution of transplanted HSPCs at the single-cell level in mice devoid of Has3-synthesized HA, provides evidence for a previously undescribed role for HA expressed on endothelial cells in directing the homing of HSPCs to the metaphysis. (Blood. 2011;118(6):1516-1524)
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROGENITOR CELLS; ENDOTHELIAL SELECTINS; STEM/PROGENITOR CELLS; ADHESION MOLECULE-1; CHEMOKINE SDF-1; HYALURONIC-ACID; MARROW NICHES; OSTEOPONTIN; TRANSPLANTATION; RECONSTITUTION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Jun 2020 05:39 |
| Last Modified: | 03 Jun 2020 05:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20403 |
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