Anoctamins

Kunzelmann, Karl and Tian, Yuemin and Martins, Joana Raquel and Faria, Diana and Kongsuphol, Patthara and Ousingsawat, Jiraporn and Thevenod, Frank and Roussa, Eleni and Rock, Jason and Schreiber, Rainer (2011) Anoctamins. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 462 (2). pp. 195-208. ISSN 0031-6768, 1432-2013

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Abstract

Endogenous Ca2+-activated Cl-channels (CaCC) demonstrate biophysical and pharmacological properties that are well represented in cells overexpressing anoctamin 1 (Ano 1, TMEM16A), a protein that has been identified recently as CaCC. Proteins of the anoctamin family (anoctamin 1-10, TMEM16A-K) are widely expressed. The number of reports demonstrating their physiological and clinical relevance is quickly rising. Anoctamins gain additional interest through their potential role in cell volume regulation and malignancy. Available data suggest that Ano 1 forms stable dimers and probably liaise with accessory proteins such as calmodulin or other anoctamins. In order to understand how anoctamins produce Ca2+-activated Cl- currents, it will be necessary to obtain better insight into their molecular structure, interactions with partner proteins, and mode of activation.

Item Type:	Article
Uncontrolled Keywords:	ACTIVATED CHLORIDE CHANNELS; CA2+-ACTIVATED CL-CHANNELS; AGE-DEPENDENT DIARRHEA; ION CHANNELS; TRANSMEMBRANE PROTEIN; TRANSCRIPTOME ANALYSIS; INTERSTITIAL-CELLS; SENSORY NEURONS; MOLECULAR-BASIS; LUNG LIQUID; Ca2+-activated Cl- currents; CaCC; TMEM16A; Ano 1; Anoctamin; TMEM16B; TMEM16E; TMEM16F; TMEM16G; TMEM16H; TMEM16J; TMEM16K; Cystic fibrosis; Proliferation; Cancer; Development, SHH
Subjects:	500 Science > 570 Life sciences
Divisions:	Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Karl Kunzelmann
Depositing User:	Petra Gürster
Date Deposited:	30 Apr 2020 10:09
Last Modified:	30 Apr 2020 10:09
URI:	https://pred.uni-regensburg.de/id/eprint/20442

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