Neumann, I. D. and Wegener, G. and Homberg, J. R. and Cohen, H. and Slattery, D. A. and Zohar, J. and Olivier, J. D. A. and Mathe, A. A. (2011) Animal models of depression and anxiety: What do they tell us about human condition? PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 35 (6). pp. 1357-1375. ISSN 0278-5846, 1878-4216
Full text not available from this repository. (Request a copy)Abstract
While modern neurobiology methods are necessary they are not sufficient to elucidate etiology and pathophysiology of affective disorders and develop new treatments. Achievement of these goals is contingent on applying cutting edge methods on appropriate disease models. In this review, the authors present four rodent models with good face-, construct-, and predictive-validity: the Flinders Sensitive rat line (FSL); the genetically "anxious" High Anxiety-like Behavior (HAB) line; the serotonin transporter knockout 5-HTT-/- rat and mouse lines; and the post-traumatic stress disorder (PTSD) model induced by exposure to predator scent, that they have employed to investigate the nature of depression and anxiety. (C) 2010 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FLINDERS SENSITIVE LINE; POSTTRAUMATIC-STRESS-DISORDER; CORTICOTROPIN-RELEASING HORMONE; SEROTONIN TRANSPORTER GENE; PITUITARY-ADRENAL AXIS; NEUROPEPTIDE-Y CONCENTRATIONS; NEUROTROPHIC FACTOR BDNF; CHRONIC MILD STRESS; KNOCK-OUT MICE; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; Animal models; Anxiety; Depression; PTSD; Translational |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 30 Apr 2020 10:11 |
| Last Modified: | 30 Apr 2020 10:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20456 |
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