Holweg, Alexander and Schnare, Markus and Gessner, Andre (2011) The bactericidal/permeability-increasing protein (BPI) in the innate defence of the lower airways. BIOCHEMICAL SOCIETY TRANSACTIONS, 39. pp. 1045-1050. ISSN 0300-5127, 1470-8752
Full text not available from this repository. (Request a copy)Abstract
The human BPI (bactericidal/permeability-increasing protein), stored in primary azurophilic granula of neutrophil granulocytes and produced by mucosal epithelia, has been known for decades to bind LPS (lipopolysaccharide) with very high affinity and to efficiently kill Gram-negative bacteria. Thus BPI potentially represents a central component of the innate immune system to directly combat microbes and modulate subsequent adaptive immune responses. Especially in the lungs, which are frequently exposed to a variety of inhaled pathogens, antimicrobial innate defence molecules such as BPI, are of exceptional relevance. In the present review, we highlight possible functions of BPI during acute pneumonia and CF (cystic fibrosis)-associated chronic infections in the lung.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GRAM-NEGATIVE BACTERIA; CYSTIC-FIBROSIS PATIENTS; LIPOPOLYSACCHARIDE-BINDING PROTEIN; AMINO-TERMINAL FRAGMENT; PSEUDOMONAS-AERUGINOSA; INDUCED EXPRESSION; HOST-DEFENSE; IN-VITRO; DISEASE; INFECTION; antimicrobial peptide; bactericidal/permeability-increasing protein (BPI); cystic fibrosis; lung innate immunity; pneumonia |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Jun 2020 04:26 |
| Last Modified: | 05 Jun 2020 04:26 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20457 |
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