Kolb, Christof and Schmidt, Roland and Dietl, Josef U. and Weyerbrock, Sonja and Morgenstern, Martin and Fleckenstein, Martin and Beier, Thomas and Von Bary, Christian and Mackes, Karl G. and Widmaier, Jochen and Kreuzer, Joerg and Semmler, Verena and Zrenner, Bernhard (2011) Reduction of Right Ventricular Pacing with Advanced Atrioventricular Search Hysteresis: Results of the PREVENT Study. PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 34 (8). pp. 975-983. ISSN 0147-8389, 1540-8159
Full text not available from this repository. (Request a copy)Abstract
Background: Right ventricular pacing predisposes to the development of heart failure and atrial fibrillation. Automatic atrioventricular search hysteresis (AVSH) is a commonly used strategy to decrease the percentage of right ventricular pacing (% VP) in patients without permanent AV block, but the results have not been optimal. Methods: The randomized, crossover PREVENT study evaluated whether an enhanced AVSH with two new features can reduce % VP compared with standard AVSH. The new features are the repetitive hysteresis [switch from extended to basic AV delay after a consistent loss of intrinsic AV conduction (IAVC) lasting for six consecutive atrial cycles] and the scan hysteresis (periodic IAVC search extension over six consecutive atrial cycles). Both standard AVSH and enhanced AVSH performed a periodic IAVC search every 180 cardiac cycles and operated with a basic AV-delay of 225 ms and a rate-independent maximum AV-delay of 300 ms for paced and sensed atrial events. Results: Among 178 patients, 53.4% had no evidence of AV block at enrollment and 46.6% had history of intermittent AV block. The median % VP was decreased by enhanced AVSH compared to standard AVSH (4.0% vs 5.5%, P < 0.001), particularly in patients with a history of AV block (21.4% vs 25.5%, P < 0.001). The primary study hypothesis that 25% of all patients would experience > 20% relative % VP reduction was not met as 46 (25.8%) patients (95% confidence interval, 20.5-31.8%) presented such relative reduction. Conclusion: The enhanced AVSH algorithm reduces % VP compared with standard AVSH in patients with intermittent AV block. (PACE 2011;34:975-983)
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IMPLANTABLE CARDIOVERTER-DEFIBRILLATORS; SINUS NODE DYSFUNCTION; DUAL-CHAMBER ICDS; ATRIAL-FIBRILLATION; SINGLE-CHAMBER; AV-INTERVAL; PACEMAKER; MODE; DELAY; CONDUCTION; minimizing ventricular pacing; atrioventricular search hysteresis; sinus node disease; intermittent atrioventricular block; pacemaker |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Jun 2020 08:54 |
| Last Modified: | 03 Jun 2020 08:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20464 |
Actions (login required)
 |
View Item |
