Quint, Karl and Agaimy, Abbas and Di Fazio, Pietro and Montalbano, Roberta and Steindorf, Claudia and Jung, Rudolf and Hellerbrand, Claus and Hartmann, Arndt and Sitter, Helmut and Neureiter, Daniel and Ocker, Matthias (2011) Clinical significance of histone deacetylases 1, 2, 3, and 7: HDAC2 is an independent predictor of survival in HCC. VIRCHOWS ARCHIV, 459 (2). pp. 129-139. ISSN 0945-6317,
Full text not available from this repository. (Request a copy)Abstract
Histone deacetylases (HDAC) are responsible for the transcriptional control of genes through chromatin remodeling and control tumor suppressor genes. In several tumors, their expression has been linked to clinicopathological factors and patient survival. This study investigates HDACs 1, 2, 3, and 7 expressions in hepatocellular carcinoma (HCC) and their correlation with clinical data and patient survival. Tissue microarrays of 170 surgically resected primary HCCs and adjacent uninvolved tissue were evaluated immunohistochemically for the expression of HDACs 1, 2, 3, 7, and Ki-67 and were analyzed with respect to clinicopathological data and patient survival. HDACs 1, 2, 3, and Ki-67 were expressed significantly higher in cancer cells compared to normal tissue (HDAC1: p = 0.034, HDACs 2 and 3 and Ki-67: p < 0.001), while HDAC7 expression did not differ between HCC and non-cancerous liver tissue. In tumor tissue HDACs 1-3 expression levels showed high concordance with each other, Ki-67 and tumor grade (p < 0.001). High HDAC2 expression was associated with poor survival in low-grade and early-stage tumors (p < 0.05). The expression of the HDACs 1, 2, and 3 (but not HDAC7) isoenzymes correlates with clinicopathological factors, and HDAC2 expression has an impact on patient survival.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEPATOCELLULAR-CARCINOMA; CLASS-I; TARGETED THERAPIES; END-POINTS; EXPRESSION; CANCER; BIOMARKERS; PROGNOSIS; CELLS; ADENOCARCINOMAS; Correlation analysis; Expression analysis; Hepatocellular carcinoma; Histone deacetylases; Overall survival; Tissue microarray |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Jun 2020 12:57 |
| Last Modified: | 03 Jun 2020 12:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20466 |
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