Shariat, Shahrokh F. and Favaretto, Ricardo L. and Gupta, Amit and Fritsche, Hans-Martin and Matsumoto, Kazumasa and Kassouf, Wassim and Walton, Thomas J. and Tritschler, Stefan and Baba, Shiro and Matsushita, Kazuhito and Bastian, Patrick J. and Martinez-Salamanca, Juan I. and Seitz, Christian and Pycha, Armin and Otto, Wolfgang and Karakiewicz, Pierre I. and Ficarra, Vincenzo and Novara, Giacomo (2011) Gender differences in radical nephroureterectomy for upper tract urothelial carcinoma. WORLD JOURNAL OF UROLOGY, 29 (4). pp. 481-486. ISSN 0724-4983,
Full text not available from this repository. (Request a copy)Abstract
Women have been associated with adverse outcomes after radical cystectomy for lower tract urothelial carcinoma. We evaluated the prognostic value of gender in an international cohort of patients treated with radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). We retrospectively studied 754 patients treated with RNU for UTUC without neoadjuvant chemotherapy at nine centers located in Asia, Canada, and Europe. Univariable and multivariable Cox regression analyses were used to address recurrence-free (RFS) and cancer-specific survival (CSS) estimates. Median follow-up was 40 months (interquartile range: 18-75). The majority of patients was of men (516, 68.4%). Women were older than men at the time of RNU (median: 69.2 vs. 66.5 years; P = 0.0003). Women were less likely to have high-grade disease, undergo lymph node dissection, and to receive adjuvant chemotherapy. Gender was not associated with pathologic stage, lymph node metastasis, lymphovascular invasion, concomitant CIS, tumor architecture, or tumor necrosis. On univariable Cox regression analyses, there was no association between gender and cancer recurrence (P = 0.76) or cancer-specific mortality (P = 0.30). On multivariable Cox regression analyses that adjusted for the effects of clinicopathologic features, gender was not associated with disease recurrence (P = 0.47) or cancer-specific survival (P = 0.15). We found no difference in histopathologic features and outcomes between men and women treated with RNU for UTUC. Nevertheless, epidemiologic and mechanistic molecular studies should be encouraged to design, analyze, and report gender-specific associations to aid in our understanding of gender impact on UTUC incidence, progression, and metastasis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LARGE MULTICENTER; OUTCOMES; CANCER; CYSTECTOMY; PREDICTOR; Gender; Prognosis; Upper urinary tract; Urothelial carcinoma; Nephroureterectomy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Jun 2020 04:34 |
| Last Modified: | 05 Jun 2020 04:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20474 |
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