Keck, Bastian and Stoehr, Robert and Wach, Sven and Rogler, Anja and Hofstaedter, Ferdinand and Lehmann, Jan and Montironi, Rodolfo and Sibonye, Mathilde and Fritsche, Hans M. and Lopez-Beltran, Antonio and Epstein, Jonathan I. and Wullich, Bernd and Hartmann, Arndt (2011) The plasmacytoid carcinoma of the bladder-rare variant of aggressive urothelial carcinoma. INTERNATIONAL JOURNAL OF CANCER, 129 (2). pp. 346-354. ISSN 0020-7136,
Full text not available from this repository. (Request a copy)Abstract
The WHO 2004 classification defines new histological and molecular variants of urothelial carcinoma. However, there are limited data available on the clinicopathological characteristics or prognosis of these variants. We present histopathological, molecular and clinical data of 32 plasmacytoid carcinomas of the bladder (PUC) showing that PUC is a high-grade tumor with molecular features of aggressive urothelial carcinoma, usually diagnosed in advanced pathological stage (64% pT3, 23% pT4) showing metastases in 60% of the patients. Average survival of our cohort of PUC treated with radical cystectomy and adjuvant chemotherapy was lower than what is typically seen for comparable conventional urothelial carcinomas. Eighty-seven percent of the PUCs showed a negative or strongly reduced membranous staining of E-cadherin. beta-Catenin staining was negative in 22.5%, and 16.7% of the remaining tumors showed nuclear accumulation. Aberrant CK20 expression (negative or >10% of cells stained) and negative CK7 staining was found in 100% and 22.6%, respectively. Ninety-seven percent revealed positive staining for PAN-CK. CD138 was positive in 78%, whereas MUM-1 expression was negative in all cases. Multitarget fluorescence in situ hybridization showed all PUCs to be highly aneuploid and polysomic. Deletions on chromosome 9p21 seem to play an important role in this variant. FGFR3 and PIK3CA mutation analyses yielded no mutations in any of the PUCs analyzed. TP53 mutation analysis showed mutations in 29%. In summary, PUC is an aggressive variant of bladder cancer with molecular features of advanced bladder cancer and evidence of WNT pathway activation in some of the cases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSITIONAL-CELL CARCINOMA; IN-SITU HYBRIDIZATION; GROWTH-FACTOR RECEPTOR-3; E-CADHERIN; RADICAL CYSTECTOMY; BREAST-CANCER; PROGNOSTIC VALUE; URINARY-BLADDER; FGFR3 MUTATIONS; ALPHA-CATENIN; plasmacytoid; urothelial carcinoma; FISH; immunohistochemistry; chemotherapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Jun 2020 05:08 |
| Last Modified: | 08 Jun 2020 05:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20540 |
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