Viale-Bouroncle, Sandra and Voellner, Florian and Moehl, Christoph and Kuepper, Kevin and Brockhoff, Gero and Reichert, Torsten E. and Schmalz, Gottfried and Morsczeck, Christian (2011) Soft matrix supports osteogenic differentiation of human dental follicle cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 410 (3). pp. 587-592. ISSN 0006-291X,
Full text not available from this repository. (Request a copy)Abstract
The differentiation of stem cells can be directed by the grade of stiffness of the developed tissue cells. For example a rigid extracellular matrix supports the osteogenic differentiation in bone marrow derived mesenchymal stem cells (MSCs). However, less is known about the relation of extracellular matrix stiffness and cell differentiation of ectomesenchymal dental precursor cells. Our study examined for the first time the influence of the surface stiffness on the proliferation and osteogenic differentiation of human dental follicle cells (DFCs). Cell proliferation of DFCs was only slightly decreased on cell culture surfaces with a bone-like stiffness. The osteogenic differentiation in DFCs could only be initiated with a dexamethasone based differentiation medium after using varying stiffness. Here, the softest surface improved the induction of osteogenic differentiation in comparison to that with the highest stiffness. In conclusion, different to bone marrow derived MSCs, soft ECMs have a superior capacity to support the osteogenic differentiation of DFCs. (C) 2011 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STEM-CELLS; IN-VITRO; INTERPLAY; TEETH; BONE; Dental follicle cells; PDMS; Differentiation; Proliferation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Jun 2020 08:40 |
| Last Modified: | 05 Jun 2020 08:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20545 |
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