Frank, Gabriele and Hennig-Fast, Kristina and Kluenemann, Hans H. and Schmitz, Gerd and Greenlee, Mark W. (2011) Differential Impact of ApoE epsilon 4 on Cortical Activation During Famous Face Recognition in Cognitively Intact Individuals and Patients With Amnestic Mild Cognitive Impairment. ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 25 (3). pp. 250-261. ISSN 0893-0341,
Full text not available from this repository. (Request a copy)Abstract
This study explores the neurofunctional correlates of the recognition of famous faces in patients with amnestic mild cognitive impairment (aMCI) and healthy controls depending on the genetic risk factor, Apolipoprotein E (ApoE) epsilon 4. An event-related functional magnetic resonance imaging experiment was conducted while participants discriminated between famous and nonfamous faces. We compared the results of 32 healthy controls [ 17 ApoE e4 carriers (E4+); 15 noncarriers (E4-)] with those of 30 patients with aMCI (16 E4+; 14 E4-). Despite comparable task performance, patients with aMCI, E4+ showed significantly less activation in a large cortical network including the left parahippocampal gyrus than patients with aMCI E4-. Furthermore, in the aMCI group, we found significantly reduced activation in the left parahippocampal gyrus and posterior cingulate cortex compared with the control group. Our results show that critical regions of the brain show functional decline associated with major risk factors, such as ApoE epsilon 4 allele and neuropsychological signs of aMCI for the development of Alzheimer disease. Importantly, the ApoE genotype seems to influence cortical activation in patients with aMCI and to a lesser degree in healthy controls as well, who are without any cognitive symptoms.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MEDIAL TEMPORAL-LOBE; STRUCTURAL BRAIN ALTERATIONS; SEMANTIC MEMORY IMPAIRMENT; ALZHEIMERS-DISEASE; HIPPOCAMPAL ACTIVATION; FUNCTIONAL MRI; GENETIC RISK; FMRI; ADULTS; RESPONSES; Alzheimer disease; amnestic mild cognitive impairment; ApoE genotype; famous faces recognition; fMRI; medial temporal lobe |
| Subjects: | 100 Philosophy & psychology > 150 Psychology 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin Medicine > Lehrstuhl für Psychiatrie und Psychotherapie Human Sciences > Institut für Psychologie > Lehrstuhl für Psychologie I (Allgemeine Psychologie I und Methodenlehre) - Prof. Dr. Mark W. Greenlee |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Jun 2020 06:31 |
| Last Modified: | 08 Jun 2020 06:31 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20568 |
Actions (login required)
 |
View Item |
