Twardziok, Monika and Schroeder, Paul C. and Krusche, Johanna and Casaca, Vera I. and Illi, Sabina and Boeck, Andreas and Loss, Georg J. and Kabesch, Michael and Toncheva, Antoaneta A. and Roduit, Caroline and Depner, Martin and Genuneit, Jon and Renz, Harald and Roponen, Marjut and Weber, Juliane and Braun-Fahrlander, Charlotte and Riedler, Josef and Lauener, Roger and Vuitton, Dominique Angele and Dalphin, Jean-Charles and Pekkanen, Juha and von Mutius, Erika and Schaub, Bianca and Hyvarinen, Anne and Karvonen, Anne M. and Kirjavainen, Pirkka V. and Remes, Sami and Kaulek, Vincent and Dalphin, Marie-Laure and Ege, Markus and Pfefferle, Petra I. and Doekes, Gert (2017) Asthmatic farm children show increased CD3(+) CD8(low) T-cells compared to non-asthmatic farm children. CLINICAL IMMUNOLOGY, 183. pp. 285-292. ISSN 1521-6616, 1521-7035
Full text not available from this repository. (Request a copy)Abstract
Several studies report an important role of CD8(+) cytotoxic T-cells in atopy. Farm children show protection against atopy development, partly explained by CD4(+) T-cell subtypes. Additional effects of CD8(+) T-cells are unknown being investigated in this study within the PASTURE/EFRAIM birth cohort in PBMCs from farming and non-farming 6-year-old (N = 76) German children. CD3(+) CD8(+) CD25(+) T-cells were analyzed by flow cytometry. Genotyping of 17q21 locus-SNPs associated with childhood asthma was performed. No differences in CD8(+) T-cell subsets were seen between farmers and non-farmers regardless of asthma. Among farm children, asthmatics displayed increased CD3(+) CD8(low)(CD25(+)) T-cells compared to non-asthmatics. Asthmatic farm children exhibited a lower PI-induced stimulatory capacity of CD3(+) CD8(low)(CD25(+)) cells and a lower IFN-gamma secretion than non-asthmatic farm children. Among farm children with GSDMB and ORMDL3 risk alleles, asthmatics displayed higher CD3(+) CD8(low) cells than non-asthmatics. Our data indicates a specific role of CD8(low) T-cells in asthmatic farm children. (C) 2017 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BROWN-NORWAY RATS; ALLERGIC DISEASE; CHILDHOOD ASTHMA; EXPOSURE; EXPRESSION; PHENOTYPE; WHEEZE; RISK; AGE; DIFFERENTIATION; CD8(+); CD8(low); Childhood; Farm-exposure |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:19 |
| Last Modified: | 19 Feb 2019 14:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2059 |
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