Schreml, Stephan and Meier, Robert J. and Wolfbeis, Otto S. and Maisch, Tim and Szeimies, Rolf-Markus and Landthaler, Michael and Regensburger, Johannes and Santarelli, Francesco and Klimant, Ingo and Babilas, Philipp (2011) 2D luminescence imaging of physiological wound oxygenation. EXPERIMENTAL DERMATOLOGY, 20 (7). pp. 550-554. ISSN 0906-6705,
Full text not available from this repository. (Request a copy)Abstract
In cutaneous wound healing, the role of oxygen in vivo is poorly understood. We studied wound surface pO(2) during physiological wound healing in humans. Split-thickness skin graft donor sites (n = 12) served as standardized wound models. Wound surface pO(2) was measured at 1, 6 and 14 days after split-skin harvesting using two-dimensional luminescence lifetime imaging (2D-LLI) of palladium(II)-meso-tetraphenyl-tetrabenzoporphyrin (Pd-TPTBP) in polystyrene-co-acrylonitrile (PSAN) particles on transparent foils. In another experiment, we removed the stratum corneum (SC) on the volar forearm (n = 10) by tape strippings to study the impact of the SC on the epidermal oxygen barrier. Split-skin donor site pO(2) significantly decreased during the time course of physiological healing. Regional differences in pO(2) within donor site wounds were visualized for the first time in literature. No difference was found in pO(2) before and after SC removal, showing that the SC is not a major constituent of the epidermal oxygen barrier.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IN-VIVO; EPIDERMAL THICKNESS; SUPERFICIAL WOUNDS; STRATUM-CORNEUM; SKIN; TENSION; SENSORS; SPECTROSCOPY; ATMOSPHERE; DRESSINGS; epidermal barrier; luminescence imaging; oxygen; split-skin; wound healing |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Chemo- und Biosensorik (Prof. Antje J. Bäumner, formerly Prof. Wolfbeis) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Jun 2020 05:19 |
| Last Modified: | 09 Jun 2020 05:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20612 |
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