Kohl, Z. and Uyanik, G. and Luerding, R. and Schuierer, G. and Bogdahn, U. and Schroeder, M. and Weidner, Norbert (2011) Selective bilateral hippocampal lesions after theophylline-induced status epilepticus causes a permanent amnesic syndrome. JOURNAL OF CLINICAL NEUROSCIENCE, 18 (7). pp. 964-966. ISSN 0967-5868, 1532-2653
Full text not available from this repository. (Request a copy)Abstract
Theophylline is known to increase the risk of epileptic seizures and might have a role in seizure-induced brain damage. We present a 55-year-old man who developed an amnesic syndrome after status epilepticus, caused by accidental theophylline intoxication. Imaging studies revealed acute, selective bilateral hippocampal damage, which corresponded to severe disturbances in bilateral temporal functions on neuropsychological testing. Three months later, the memory deficits persisted, while imaging exhibited bilateral atrophy of the hippocampus. Upon his long-term, 18-month follow-up, the patient demonstrated improvements in his daily living abilities, despite the persistence of bilateral temporal deficits. This report provides evidence that theophylline has the potential to provoke permanent seizure-induced neural damage, presumably via inhibition of adenosine receptors, and especially in vulnerable regions of the brain, such as the hippocampus. (C) 2011 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EPILEPSY; DAMAGE; SEIZURES; INJURY; Anterograde amnesia; Hippocampal atrophy; Intoxication; Theophylline |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Jun 2020 05:39 |
| Last Modified: | 09 Jun 2020 05:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20616 |
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