Viale-Bouroncle, Sandra and Bey, Brigitte and Reichert, Torsten E. and Schmalz, Gottfried and Morsczeck, Christian (2011) beta-Tricalcium-phosphate stimulates the differentiation of dental follicle cells. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 22 (7). pp. 1719-1724. ISSN 0957-4530, 1573-4838
Full text not available from this repository. (Request a copy)Abstract
The use of dental progenitor cells is a straightforward strategy for regenerative dentistry. For example a cell based therapy with dental follicle cells (DFCs) could be a novel therapeutic strategy for the regeneration of oral tissues in the future. For the regeneration of large bone defects for example dental progenitor cells have to be combined with bone substitutes as scaffolds. This study therefore investigated cell attachment (scanning electron microscopy), cell vitality/proliferation (WST-1 assay) and cell differentiation (under in vitro conditions) of human DFCs on synthetic beta-tricalcium phosphate (TCP). DFCs showed considerable cell attachment and proliferation on TCP. Moreover, TCP stimulates osteogenic differentiation in comparison to DFCs with a standard protocol. Here, for example, the osteoblast marker bone sialoprotein (BSP) was highly expressed on TCP, but almost absent in differentiated DFCs without TCP. In conclusion, our study shows that TCP is an excellent scaffold for DFCs for oral tissue regeneration.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PULP-DERIVED CELLS; IN-VITRO; STEM-CELLS; REGENERATION; VIVO; TISSUE; TEETH; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Jun 2020 05:44 |
| Last Modified: | 09 Jun 2020 05:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20617 |
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