Lukas, Michael and Bredewold, Remco and Landgraf, Rainer and Neumann, Inga D. and Veenema, Alexa H. (2011) Early life stress impairs social recognition due to a blunted response of vasopressin release within the septum of adult male rats. PSYCHONEUROENDOCRINOLOGY, 36 (6). pp. 843-853. ISSN 0306-4530,
Full text not available from this repository. (Request a copy)Abstract
Early life stress poses a risk for the development of psychopathologies characterized by disturbed emotional, social, and cognitive performance. We used maternal separation (MS, 3 h daily, postnatal days 1-14) to test whether early life stress impairs social recognition performance in juvenile (5-week-old) and adult (16-week-old) male Wistar rats. Social recognition was tested in the social discrimination test and defined by increased investigation by the experimental rat towards a novel rat compared with a previously encountered rat. Juvenile control and MS rats demonstrated successful social recognition at inter-exposure intervals of 30 and 60 min. However, unlike adult control rats, adult MS rats failed to discriminate between a previously encountered and a novel rat after 60 min. The social recognition impairment of adult MS rats was accompanied by a lack of a rise in arginine vasopressin (AVP) release within the lateral septum seen during social memory acquisition in adult control rats. This blunted response of septal AVP release was social stimulus-specific because forced swimming induced a rise in septal AVP release in both control and MS rats. Retrodialysis of AVP (1 mu g/ml, 3.3 mu l/min, 30 min) into the lateral septum during social memory acquisition restored social recognition in adult MS rats at the 60-min interval. These studies demonstrate that MS impairs social recognition performance in adult rats, which is likely caused by blunted septal AVP activation. Impaired social recognition may be linked to MS-induced changes in other social behaviors like aggression as shown previously. (C) 2010 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MATERNAL SEPARATION; LATERAL SEPTUM; HYPOTHALAMIC VASOPRESSIN; INTERMALE AGGRESSION; STRIA TERMINALIS; CHILDHOOD TRAUMA; EARLY EXPERIENCE; MESSENGER-RNA; C57BL/6 MICE; BED NUCLEUS; Early life stress; Juvenile; Lateral septum; Maternal separation; Microdialysis; Rats; Social discrimination; Social memory; Social recognition; Vasopressin |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Jun 2020 06:01 |
| Last Modified: | 09 Jun 2020 06:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20627 |
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