Kosmidis, Stylianos and Botella, Jose A. and Mandilaras, Konstantinos and Schneuwly, Stephan and Skoulakis, Efthimios M. C. and Rouault, Tracey A. and Missirlis, Fanis (2011) Ferritin overexpression in Drosophila glia leads to iron deposition in the optic lobes and late-onset behavioral defects. NEUROBIOLOGY OF DISEASE, 43 (1). pp. 213-219. ISSN 0969-9961,
Full text not available from this repository. (Request a copy)Abstract
Cellular and organismal iron storage depends on the function of the ferritin protein complex in insects and mammals alike. In the central nervous system of insects, the distribution and relevance of ferritin remain unclear, though ferritin has been implicated in Drosophila models of Alzheimers' and Parkinsons' disease and in Aluminum-induced neurodegeneration. Here we show that transgene-derived expression of ferritin subunits in glial cells of Drosophila melanogaster causes a late-onset behavioral decline, characterized by loss of circadian rhythms in constant darkness and impairment of elicited locomotor responses. Anatomical analysis of the affected brains revealed crystalline inclusions of iron-loaded ferritin in a subpopulation of glial cells but not significant neurodegeneration. Although transgene-induced glial ferritin expression was well tolerated throughout development and in young flies, it turned disadvantageous at older age. The flies we characterize in this report contribute to the study of ferritin in the Drosophila brain and can be used to assess the contribution of glial iron metabolism in neurodegenerative models of disease. (C) 2011 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RESTLESS LEGS SYNDROME; KINASE-ASSOCIATED NEURODEGENERATION; DOPAMINERGIC NEURON LOSS; OXIDATIVE STRESS; PARKINSONS-DISEASE; MITOCHONDRIAL-FUNCTION; RETINAL DEGENERATION; RESPONSIVE ELEMENT; FRIEDREICHS-ATAXIA; ALPHA-SYNUCLEIN; Optic lamina; Inclusions; Metals; Circadian clock; Restless legs; Hyperferritinemia |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Entwicklungsbiologie (Prof. Dr. Stephan Schneuwly) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Jun 2020 06:26 |
| Last Modified: | 09 Jun 2020 06:26 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20636 |
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