Buechler, Christa and Wanninger, Josef and Neumeier, Markus (2011) Adiponectin, a key adipokine in obesity related liver diseases. WORLD JOURNAL OF GASTROENTEROLOGY, 17 (23). pp. 2801-2811. ISSN 1007-9327, 2219-2840
Full text not available from this repository. (Request a copy)Abstract
Non-alcoholic fatty liver disease (NAFLD) comprising hepatic steatosis, non-alcoholic steatohepatitis (NASH), and progressive liver fibrosis is considered the most common liver disease in western countries. Fatty liver is more prevalent in overweight than normal-weight people and liver fat positively correlates with hepatic insulin resistance. Hepatic steatosis is regarded as a benign stage of NAFLD but may progress to NASH in a subgroup of patients. Besides liver biopsy no diagnostic tools to identify patients with NASH are available, and no effective treatment has been established. Visceral obesity is a main risk factor for NAFLD and inappropriate storage of triglycerides in adipocytes and higher concentrations of free fatty acids may add to increased hepatic lipid storage, insulin resistance, and progressive liver damage. Most of the adipose tissue-derived proteins are elevated in obesity and may contribute to systemic inflammation and liver damage. Adiponectin is highly abundant in human serum but its levels are reduced in obesity and are even lower in patients with hepatic steatosis or NASH. Adiponectin antagonizes excess lipid storage in the liver and protects from inflammation and fibrosis. This review aims to give a short survey on NAFLD and the hepatoprotective effects of adiponectin. (C) 2011 Baishideng. All rights reserved.
| Item Type: | Article |
|---|---|
| Additional Information: | DOI war falsch angegeben, sie ist schon im Artikel falsch gewesen, deshalb habe ich sie herausgenommen /gup |
| Uncontrolled Keywords: | NONALCOHOLIC FATTY LIVER; GAMMA LIGAND ROSIGLITAZONE; HEPATIC INSULIN-RESISTANCE; COMPLEMENT-RELATED PROTEIN; NF-KAPPA-B; ADIPOSE-TISSUE; METABOLIC SYNDROME; PLASMA ADIPONECTIN; WEIGHT-LOSS; TNF-ALPHA; Hepatic steatosis; Non-alcoholic steatohepatitis; Adiponectin; Obesity; Adipose tissue |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 30 Apr 2020 08:43 |
| Last Modified: | 30 Apr 2020 08:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20652 |
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