McKay, Gareth J. and Silvestri, Giuliana and Chakravarthy, Usha and Dasari, Shilpa and Fritsche, Lars G. and Weber, Bernhard H. and Keilhauer, Claudia N. and Klein, Michael L. and Francis, Peter J. and Klaver, Caroline C. and Vingerling, Johannes R. and Ho, Lintje and De Jong, Paulus T. D. V. and Dean, Michael and Sawitzke, Julie and Baird, Paul N. and Guymer, Robyn H. and Stambolian, Dwight and Orlin, Anton and Seddon, Johanna M. and Peter, Inga and Wright, Alan F. and Hayward, Caroline and Lotery, Andrew J. and Ennis, Sarah and Gorin, Michael B. and Weeks, Daniel E. and Kuo, Chia-Ling and Hingorani, Aroon D. and Sofat, Reecha and Cipriani, Valentina and Swaroop, Anand and Othman, Mohammad and Kanda, Atsuhiro and Chen, Wei and Abecasis, Goncalo R. and Yates, John R. and Webster, Andrew R. and Moore, Anthony T. and Seland, Johan H. and Rahu, Mati and Soubrane, Gisele and Tomazzoli, Laura and Topouzis, Fotis and Vioque, Jesus and Young, Ian S. and Fletcher, Astrid E. and Patterson, Chris C. (2011) Variations in Apolipoprotein E Frequency With Age in a Pooled Analysis of a Large Group of Older People. AMERICAN JOURNAL OF EPIDEMIOLOGY, 173 (12). pp. 1357-1364. ISSN 0002-9262
Full text not available from this repository. (Request a copy)Abstract
Variation in the apolipoprotein E gene (APOE) has been reported to be associated with longevity in humans. The authors assessed the allelic distribution of APOE isoforms epsilon 2, epsilon 3, and epsilon 4 among 10,623 participants from 15 case-control and cohort studies of age-related macular degeneration (AMD) in populations of European ancestry (study dates ranged from 1990 to 2009). The authors included only the 10,623 control subjects from these studies who were classified as having no evidence of AMD, since variation within the APOE gene has previously been associated with AMD. In an analysis stratified by study center, gender, and smoking status, there was a decreasing frequency of the APOE epsilon 4 isoform with increasing age (chi(2) for trend 14.9 (1 df); P = 0.0001), with a concomitant increase in the epsilon 3 isoform (chi(2) for trend 11.3 (1 df); P = 0.001). The association with age was strongest in epsilon 4 homozygotes; the frequency of epsilon 4 homozygosity decreased from 2.7% for participants aged 60 years or less to 0.8% for those over age 85 years, while the proportion of participants with the epsilon 3/epsilon 4 genotype decreased from 26.8% to 17.5% across the same age range. Gender had no significant effect on the isoform frequencies. This study provides strong support for an association of the APOE gene with human longevity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ONSET ALZHEIMERS-DISEASE; MACULAR DEGENERATION; RISK-FACTORS; E GENE; E POLYMORPHISM; APOE GENOTYPE; ASSOCIATION; LONGEVITY; GENDER; ALLELE; aged; apolipoprotein E2; apolipoprotein E3; apolipoprotein E4; apolipoproteins E; longevity; meta-analysis; multicenter study |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Humangenetik |
| Depositing User: | Petra Gürster |
| Date Deposited: | 30 Apr 2020 08:52 |
| Last Modified: | 30 Apr 2020 08:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20658 |
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