Schnitzbauer, Andreas A. and Schlitt, Hans J. and Geissler, Edward K. (2011) Influence of Immunosuppressive Drugs on the Recurrence of Hepatocellular Carcinoma After Liver Transplantation: A Gap Between Basic Science and Clinical Evidence. TRANSPLANTATION, 91 (11). pp. 1173-1176. ISSN 0041-1337
Full text not available from this repository. (Request a copy)Abstract
Effects of immunosuppressive drug on tumor development in transplantation are understudied. Tumors are especially concerning when liver transplantation recipients have a pretransplant hepatocellular carcinoma (HCC). Because immunosuppressive drugs likely influence HCC recurrence, with mammalian target of rapamycin inhibitors showing antineoplastic properties especially experimentally, we sought for practical medical guidance from published clinical studies. Although the current literature review revealed 14 studies regarding immunosuppression in this context, suggesting antitumor effects for mammalian target of rapamycin inhibitors, the quality of evidence is low. Therefore, randomized controlled trials investigating effects of immunosuppression on HCC recurrence in liver transplantation are lacking, exposing a gap between basic science knowledge and clinical evidence.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SIROLIMUS-BASED IMMUNOSUPPRESSION; SINGLE-CENTER EXPERIENCE; CANCER-TREATMENT-GROUP; INITIAL-EXPERIENCE; TUMOR RECURRENCE; RISK-FACTORS; TEMSIROLIMUS; TRIAL; RECIPIENTS; RAPAMYCIN; Hepatocellular carcinoma; Immunosuppression; mTOR; CNI; Tumor recurrence |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 30 Apr 2020 09:21 |
| Last Modified: | 30 Apr 2020 09:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20661 |
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