May, Matthias and Burger, M. and Brookman-May, S. and Otto, W. and Peter, J. and Rud, O. and Fritsche, H. -M. and Bolenz, C. and Trojan, L. and Herrmann, E. and Michel, M. S. and Wuelfing, C. and Moritz, R. and Tiemann, A. and Mueller, S. C. and Ellinger, J. and Buchner, A. and Stief, C. G. and Tilki, D. and Wieland, W. F. and Gilfrich, C. and Hoefner, T. and Hohenfellner, M. and Haferkamp, A. and Roigas, J. and Bretschneider-Ehrenberg, P. and Mueller, O. and Zacharias, M. and Gunia, S. and Bastian, P. J. (2011) Validation of pre-cystectomy nomograms for the prediction of locally advanced urothelial bladder cancer in a multicentre study. UROLOGE, 50 (6). pp. 706-713. ISSN 0340-2592,
Full text not available from this repository. (Request a copy)Abstract
Objective. Pre-cystectomy nomograms with a high predictive ability for locally advanced urothelial carcinomas of the bladder would enhance individual treatment tailoring and patient counselling. To date, there are two currently not externally validated nomograms for prediction of the tumour stages pT3-4 or lymph node involvement. Materials and methods. Data from a German multicentre cystectomy series comprising 2,477 patients with urothelial carcinoma of the bladder were applied for the validation of two US nomograms, which were originally based on the data of 726 patients (nomogram 1: prediction of pT3-4 tumours, nomogram 2: prediction of lymph node involvement). Multivariate regression models assessed the value of clinical parameters integrated in both nomograms, i.e. age, gender, cT stage, TURB grade and associated Tis. Discriminative abilities of both nomograms were assessed by ROC analyses; calibration facilitated a comparison of the predicted probability and the actual incidence of locally advanced tumour stages. Results. Of the patients, 44.5 and 25.8% demonstrated tumour stages pT3-4 and pN+, respectively. If only one case of a previously not known locally advanced carcinoma (pT3-4 and/or pN+) is considered as a staging error, the rate of understaging was 48.9% (n=1211). The predictive accuracies of the validated nomograms were 67.5 and 54.5%, respectively. The mean probabilities of pT3-4 tumours and lymph node involvement predicted by application of these nomograms were 36.7% (actual frequency 44.5%) and 20.2% (actual frequency 25.8%), respectively. Both nomograms underestimated the real incidence of locally advanced tumours. Conclusions. The present study demonstrates that prediction of locally advanced urothelial carcinomas of the bladder by both validated nomograms is not conferrable to patients of the present German cystectomy series. Hence, there is still a need for statistical models with enhanced predictive accuracy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RADICAL CYSTECTOMY; NEOADJUVANT CHEMOTHERAPY; LYMPHOVASCULAR INVASION; CARCINOMA; TOMOGRAPHY; SPECIMENS; RESECTION; TUMOR; Bladder carcinoma; Urothelial carcinoma; Radical cystectomy; Validation study; Predictive accuracy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Jun 2020 12:06 |
| Last Modified: | 09 Jun 2020 12:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20722 |
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