Plank, Tina and Frolo, Jozef and Brandi-Ruehle, Sabine and Renner, Agnes B. and Hufendiek, Karsten and Helbig, Horst and Greenlee, Mark W. (2011) Gray matter alterations in visual cortex of patients with loss of central vision due to hereditary retinal dystrophies. NEUROIMAGE, 56 (3). pp. 1556-1565. ISSN 1053-8119,
Full text not available from this repository. (Request a copy)Abstract
In patients with central visual field scotomata a large part of visual cortex is not adequately stimulated. Over time this lack of input could lead to a reduction of gray matter ill the affected cortical areas. We used Voxel Based Morphometry to investigate structural brain changes in patients with central scotomata due to hereditary retinal dystrophies and compared their results to those of normal sighted subjects. Additionally we correlated clinical and demographic characteristics like duration of disease. scotoma size, visual acuity, fixation stability and reading speed to the amount of gray matter in whole brain analyses within the patient group. We found a decrease in gray matter around the lesion projection zone in visual cortex of patients in comparison to controls. Gray matter loss along the posterior and middle portions of the calcarine sulcus is also correlated with scotoma size, indicating that indeed the lack of functional input provokes the gray matter alterations. In whole brain regression analyses within the patient group we found an additional cluster in the right superior and middle frontal gyri, slightly anterior to the frontal eye fields, where gray matter correlated positively with fixation stability. This could he regarded as a consequence of oculomotor learning. (C) 2011 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VOXEL-BASED MORPHOMETRY; LATERAL GENICULATE-NUCLEUS; STRUCTURAL BRAIN CHANGES; GREY-MATTER; MACULAR SCOTOMA; CEREBRAL-CORTEX; HUMAN ALBINISM; HUMAN GLAUCOMA; SPINAL-CORD; AMPUTATION; Hereditary macular dystrophy; Central visual field scotomas; Visual cortex; Voxel-based morphometry; Gray matter density; Gray matter volume |
| Subjects: | 100 Philosophy & psychology > 150 Psychology 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde Human Sciences > Institut für Psychologie > Lehrstuhl für Psychologie I (Allgemeine Psychologie I und Methodenlehre) - Prof. Dr. Mark W. Greenlee |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jun 2020 10:03 |
| Last Modified: | 15 Jun 2020 10:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20750 |
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