Frank, Elmar and Eichhammer, Peter and Burger, Julia and Zowe, Marc and Landgrebe, Michael and Hajak, Goeran and Langguth, Berthold (2011) Transcranial magnetic stimulation for the treatment of depression: feasibility and results under naturalistic conditions: a retrospective analysis. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 261 (4). pp. 261-266. ISSN 0940-1334, 1433-8491
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An increasing number of controlled studies strongly support an antidepressant effect of high-frequency repetitive transcranial magnetic stimulation (rTMS) over the left dorsolateral prefrontal cortex. However, these data come from highly selected study populations. Whether rTMS is a feasible therapeutic tool for the treatment of depression under naturalistic condition has not yet been addressed. Here, we report results from 232 depressive patients [aged 20-76 years, baseline Hamilton Depression Rating Score (HDRS-21) 24.0 +/- A 7.3] treated with rTMS add-on to continued psychopharmacological treatment in a naturalistic clinical setting. Two thousand stimuli of 20-Hz rTMS were applied daily over the left dorsolateral prefrontal cortex with an intensity of 110% of motor threshold. Treatment duration was individually planned and varied between 10 and 20 sessions. In average, patients received 13 +/- A 6.1 rTMS sessions. In 90% of the cases, treatment was terminated regularly. No severe side effects were observed. Only four patients stopped rTMS treatment because of side effects. Ratings with the HDRS-21 before and after treatment were available in 130 patients. The average improvement of the HDRS-21 in this subsample was 9.0 +/- A 9.2 points. Fifty-three patients had an improvement of 50% or more. These results document that rTMS is feasible, safe and well tolerated under naturalistic conditions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TREATMENT-RESISTANT DEPRESSION; MAJOR DEPRESSION; RANDOMIZED MULTICENTER; CONTROLLED-TRIAL; RTMS; SAFETY; METAANALYSIS; SYMPTOMS; EFFICACY; THERAPY; Transcranial magnetic stimulation; Depression; Treatment; Naturalistic condition; Medication-resistant depression |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jun 2020 10:29 |
| Last Modified: | 15 Jun 2020 10:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20762 |
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