Yang, Rongxi and Dick, Michelle and Marme, Frederik and Schneeweiss, Andreas and Langheinz, Anne and Hemminki, Kari and Sutter, Christian and Bugert, Peter and Wappenschmidt, Barbara and Varon, Raymonda and Schott, Sarah and Weber, Bernhard H. F. and Niederacher, Dieter and Arnold, Norbert and Meindl, Alfons and Bartram, Claus R. and Schmutzler, Rita K. and Mueller, Heiko and Arndt, Volker and Brenner, Hermann and Sohn, Christof and Burwinkel, Barbara (2011) Genetic variants within miR-126 and miR-335 are not associated with breast cancer risk. BREAST CANCER RESEARCH AND TREATMENT, 127 (2). pp. 549-554. ISSN 0167-6806,
Full text not available from this repository. (Request a copy)Abstract
MicroRNAs (miRNAs) are 20-22 nt non-coding RNAs which promote the degradation of target mRNAs or repression of the translation of mRNAs by sequence specific targeting. Many miRNAs are considered as oncogenes or tumor suppressors. MiR-126 and miR-335 play roles in the suppression of breast cancer metastasis by inhibiting tumor growth, proliferation, and cell invasion. The effects of SNPs within the two miRNAs are still unknown. In our study, we analyzed two SNPs, rs4636297 within miR-126 and rs41272366 within miR-335, in three study populations for a putative association with breast cancer risk. We compared the genotype and allele frequencies of rs4636297 and rs41272366 in 2854 cases versus 3188 controls of the three study populations independently and combined. None of the performed analyses showed statistically significant results. In conclusion, our data suggest that the two genetic variants within miR-126 and miR-335 are not associated with breast cancer risk.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MICRORNA; EXPRESSION; POLYMORPHISM; POPULATION; PROFILES; CLUSTER; MIRNA; Breast cancer; Polymorphism; miRNA; Genetic variants; SNP |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Humangenetik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jun 2020 07:05 |
| Last Modified: | 15 Jun 2020 07:05 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20789 |
Actions (login required)
 |
View Item |
