De Ridder, Dirk and Elgoyhen, Ana Belen and Romo, Ranulfo and Langguth, Berthold (2011) Phantom percepts: Tinnitus and pain as persisting aversive memory networks. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108 (20). pp. 8075-8080. ISSN 0027-8424,
Full text not available from this repository. (Request a copy)Abstract
Phantom perception refers to the conscious awareness of a percept in the absence of an external stimulus. On the basis of basic neuroscience on perception and clinical research in phantom pain and phantom sound, we propose a working model for their origin. Sensory deafferentation results in high-frequency, gamma band, synchronized neuronal activity in the sensory cortex. This activity becomes a conscious percept only if it is connected to larger coactivated "(self-)awareness" and "salience" brain networks. Through the involvement of learning mechanisms, the phantom percept becomes associated to distress, which in turn is reflected by a simultaneously coactivated nonspecific distress network consisting of the anterior cingulate cortex, anterior insula, and amygdala. Memory mechanisms play a role in the persistence of the awareness of the phantom percept, as well as in the reinforcement of the associated distress. Thus, different dynamic overlapping brain networks should be considered as targets for the treatment of this disorder.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SUBJECTIVE SENSORY EXPERIENCE; MINIMALLY CONSCIOUS STATE; LIMB PAIN; CORTICAL REORGANIZATION; AUDITORY-PERCEPTION; VEGETATIVE STATE; ACTIVITY FLUCTUATIONS; NEURAL ACTIVITY; BRAIN ACTIVITY; C-FOS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie Medicine > Zentren des Universitätsklinikums Regensburg > Tinnituszentrum |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jun 2020 09:00 |
| Last Modified: | 15 Jun 2020 09:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20818 |
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