Wanninger, Josef and Neumeier, Markus and Bauer, Sabrina and Weiss, Thomas S. and Eisinger, Kristina and Walter, Roland and Dorn, Christoph and Hellerbrand, Claus and Schaeffler, Andreas and Buechler, Christa (2011) Adiponectin induces the transforming growth factor decoy receptor BAMBI in human hepatocytes. FEBS LETTERS, 585 (9). pp. 1338-1344. ISSN 0014-5793,
Full text not available from this repository. (Request a copy)Abstract
Transforming growth factor (TGF) beta is the central cytokine in fibrotic liver diseases. We analyzed whether hepatoprotective adiponectin directly interferes with TGF beta 1 signaling in primary human hepatocytes (PHH). Adiponectin induces the TGF beta decoy receptor BMP-and activin-membrane-bound inhibitor (BAMBI) in PHH. Overexpression of BAMBI in hepatoma cells impairs TGF beta-mediated phosphorylation of SMAD2 and induction of connective tissue growth factor. BAMBI is lower in human fatty liver with a higher susceptibility to liver fibrosis and negatively correlates with BMI of the donors. Hepatic BAMBI is reduced in rodent models of liver inflammation and fibrosis. In summary, the current data show that hepatoprotective effects of adiponectin include induction of BAMBI which is reduced in human fatty liver and rodent models of metabolic liver injury. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FATTY LIVER-DISEASE; HIGH-MOLECULAR-WEIGHT; HEPATIC STELLATE CELLS; TGF-BETA; NONALCOHOLIC STEATOHEPATITIS; PLASMA ADIPONECTIN; INSULIN-RESISTANCE; SIGNALING PATHWAY; METABOLIC ACTIONS; FIBROSIS; Fatty liver disease; Liver fibrosis; Adiponectin; Transforming growth factor beta; Hepatocyte |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Jun 2020 05:26 |
| Last Modified: | 22 Jun 2020 05:26 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20834 |
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