Zunhammer, Matthias and Langguth, Berthold and Landgrebe, Michael and Frank, Elmar and Mueller, Sabine and Burger, Julia and Sand, Philipp G. and Eichhammer, Peter and Hajak, Goeran (2011) Modulation of human motor cortex excitability by valproate. PSYCHOPHARMACOLOGY, 215 (2). pp. 277-280. ISSN 0033-3158, 1432-2072
Full text not available from this repository. (Request a copy)Abstract
Rationale Valproate is widely used in the treatment of epilepsy, bipolar disorder, and chronic pain disorders, but its exact mechanisms of action is still incompletely understood. Objectives Here we used transcranial magnetic stimulation to explore effects of a single dose of 800 mg valproate on motor cortex excitability in healthy volunteers. Methods Motor threshold, peripheral maximum M-wave, cortical silent period short intracortical inhibition, intracortical facilitation, and motor evoked potential recruitment were assessed before and 1.5 h after the administration of valproate in 15 (eight male, seven female) healthy volunteers. Results None of the measures of cortical excitability were found to be altered significantly after valproate. Conclusion These results are in line with previous findings of unaffected intracortical excitability after a single dose of valproate, suggesting that valproate's immediate in vivo actions do not resemble the effects of classic GABAergic compounds.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSCRANIAL MAGNETIC STIMULATION; POWER ANALYSIS; INHIBITION; MECHANISMS; DRUGS; Anticonvulsant; Valproic acid; Human motor cortex; Excitability; Transcranial magnetic stimulation; Homeostatic plasticity |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Jun 2020 05:19 |
| Last Modified: | 22 Jun 2020 05:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20890 |
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