Torrelo, Antonio and Colmenero, Isabel and Kristal, Leonard and Navarro, Lourdes and Hafner, Christian and Hernandez-Martin, Angela and Requena, Luis and Happle, Rudolf (2011) Papular epidermal nevus with "skyline" basal cell layer (PENS). JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 64 (5). pp. 888-892. ISSN 0190-9622,
Full text not available from this repository. (Request a copy)Abstract
Background: Several types of epidermal keratinocytic nevus are recognized. Objective: We sought to describe a previously unreported keratinocytic nevus with distinctive clinical and histopathologic features in 5 patients. Methods: We performed a clinical and photographic review, and obtained skin biopsy samples for histopathologic examination from each patient. Genetic analysis to screen for fibroblast growth factor receptor 3 and phosphatidylinositol 3-kinase, catalytic, alpha hotspot mutations was performed on lesional skin from two patients. Results: Five infants (2 male, 3 female) had from 1 to 11 lesions present since birth. These consisted of 1- to 7-mm hyperkeratotic papules with a rough, flat surface and a round, commalike, rectangular, or polygonal shape. Histopathologic examination showed acanthosis with broad and rectangular rete ridges, and strikingly arranged basal cells with palisaded nuclei. Genetic testing on paraffin-embedded specimens from two patients ruled out hotspot mutations in the fibroblast growth factor receptor 3 and phosphatidylinositol 3-kinase, catalytic, alpha genes. Limitations: A small number of patients are presented. Conclusion: We propose the name "papular epidermal nevus with 'skyline' basal cell layer" (PENS) for this newly recognized condition. (J Am Acad Dermatol 2011;64:888-92.)
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | WAXY KERATOSES; MUTATIONS; CHILDHOOD; MOSAICISM; PATTERNS; DISEASE; congenital nevus; epidermal nevus; keratinocytic nevus; nevus; newborn; skin hamartoma |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Jun 2020 10:30 |
| Last Modified: | 25 Jun 2020 10:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20898 |
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