Gantner, S. and Wiesner, T. and Cerroni, L. and Lurkin, I. and Zwarthoff, E. C. and Landthaler, M. and Hafner, C. (2011) Absence of BRAF and HRAS mutations in eruptive Spitz naevi. BRITISH JOURNAL OF DERMATOLOGY, 164 (4). pp. 873-877. ISSN 0007-0963,
Full text not available from this repository. (Request a copy)Abstract
P>Background Eruptive Spitz naevi have been reported rarely in the literature. In solitary Spitz naevi, BRAF and HRAS mutations, as well as increased copy numbers of chromosome 11p have been identified. Objectives To investigate the genetic changes underlying eruptive Spitz naevi. Methods We report on a 16-year-old boy who developed multiple disseminated eruptive Spitz naevi within a few months. We analysed BRAF, HRAS, KRAS and NRAS genes in 39 naevi from this patient for hotspot mutations. Furthermore, comparative genomic hybridization analysis was performed in three lesions. Results None of the Spitz naevi displayed a mutation in the analysed genes, and no chromosomal imbalances were observed. Conclusions Our results indicate that the typical genetic alterations described in solitary Spitz naevi appear to be absent in eruptive Spitz naevi. Yet unknown alternative genetic alterations must account for this rare syndrome.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MELANOCYTIC LESIONS; MELANOMA; NEUROFIBROMAS; NRAS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Jun 2020 07:57 |
| Last Modified: | 22 Jun 2020 07:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20961 |
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