Mueller, Thomas and Lubnow, Matthias and Philipp, Alois and Schneider-Brachert, Wulf and Camboni, Daniele and Schmid, Christof and Lehle, Karla (2011) Risk of Circuit Infection in Septic Patients on Extracorporeal Membrane Oxygenation: A Preliminary Study. ARTIFICIAL ORGANS, 35 (4). E84-E90. ISSN 0160-564X,
Full text not available from this repository. (Request a copy)Abstract
Extracorporeal membrane oxygenation (ECMO) is the ultimate treatment option to improve gas exchange and decrease the aggressiveness of mechanical ventilation in septic patients with uncontrolled severe lung failure. However, potential microbiological colonization of the artificial surfaces of membrane oxygenator (MO) remains a critical issue in patients with bacteremia. The current study investigates the risk of MO infection in 10 consecutive septic patients on long-term treatment with ECMO. The flushing fluids of all investigated MOs were sterile. After incubation with nutrient solution for 14 days in one MO Enterococci spp. were isolated. In the patient concerned, a diffuse, unaccountable bleeding diathesis had developed, which stopped after exchange of the MO. Analysis of clinical parameters showed that D dimers had increased and fibrinogen levels had decreased before exchange of this MO, but standard markers of infection had remained unremarkable. In conclusion, circuit infection may be a potential cause for unexplained clinical deterioration of patients on ECMO, which therefore should be considered as an indication for exchange of the device.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RESPIRATORY-FAILURE; ADULT PATIENTS; EXPERIENCE; CHILDREN; SUPPORT; SEPSIS; TRIAL; Extracorporeal membrane oxygenation; Oxygenator; Infection; Acute respiratory distress syndrome; Sepsis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Jun 2020 05:08 |
| Last Modified: | 23 Jun 2020 05:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20998 |
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