Reinhard, Wibke and Kaess, Bernhard M. and Debiec, Radoslaw and Nelson, Christopher P. and Stark, Klaus and Tobin, Martin D. and Macfarlane, Peter W. and Tomaszewski, Maciej and Samani, Nilesh J. and Hengstenberg, Christian (2011) Heritability of Early Repolarization A Population-Based Study. CIRCULATION-CARDIOVASCULAR GENETICS, 4 (2). pp. 134-138. ISSN 1942-325X,
Full text not available from this repository. (Request a copy)Abstract
Background-Early repolarization (ER), defined by J-point elevation in 12-lead ECG, was recently associated with increased risk for idiopathic ventricular fibrillation and cardiovascular mortality. The determinants of ER are unknown. We investigated its heritability in a large, family-based cohort. Methods and Results-The study sample comprised 1877 individuals from 505 white nuclear families representative of the British general population. Standard 12-lead ECGs were evaluated for the presence of ER, defined as J-point elevation of >= 0.1 mV in at least 2 adjacent inferior (II, III, and aVF) or anterolateral (I, aVL, and V(4) through V(6)) leads. Narrow sense heritability estimates were computed adjusting for age, age(2), and sex. The prevalence of ER was 7.7% (n = 145) in the whole cohort, 5.9% (n = 56) in parents, and 9.6% (n = 89) in offspring. Heritability estimate for the presence of ER was calculated at h(2) = 0.49 (standard error = 0.14; P = 2.7*10(-4)) and was higher when restricted to its presence in inferior leads (h(2) = 0.61, standard error = 0.18, P = 4.3*10(-4)) or for the notching ER morphology (h(2) = 0.81, standard error = 0.19, P = 2.4*10(-5)). Individuals with at least 1 affected parent had a 2.5-fold increased risk for presenting with ER on ECG (odds ratio, 2.54; 95% confidence interval, 1.33 to 4.84; P = 0.005). Familial transmission was more frequent when the mother was affected (odds ratio, 3.84; 95% confidence interval, 1.41 to 10.43; P = 0.008) than when the father was affected (odds ratio, 1.82; 95% confidence interval, 0.82 to 4.03; P = 0.141), although this difference was not statistically significant (P = 0.18). Conclusions-ER is a heritable phenotype. Offspring of ER-positive parents have a 2.5-fold increased risk of presenting with ER on their ECG. (Circ Cardiovasc Genet. 2011;4:134-138.)
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ST-SEGMENT ELEVATION; SUDDEN CARDIAC DEATH; QT INTERVAL; HEART-RATE; VENTRICULAR-FIBRILLATION; CLINICAL CHARACTERISTICS; COMMON VARIANTS; BLOOD-PRESSURE; MORTALITY; ELECTROCARDIOGRAM; electrocardiography; genetics; early repolarization; J-point elevation; heritability |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Jun 2020 05:18 |
| Last Modified: | 23 Jun 2020 05:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/21010 |
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