Daugherty, Sarah E. and Pfeiffer, Ruth M. and Sigurdson, Alice J. and Hayes, Richard B. and Leitzmann, Michael and Schatzkin, Arthur and Hollenbeck, Albert R. and Silverman, Debra T. (2011) Nonsteroidal Antiinflammatory Drugs and Bladder Cancer: A Pooled Analysis. AMERICAN JOURNAL OF EPIDEMIOLOGY, 173 (7). pp. 721-730. ISSN 0002-9262, 1476-6256
Full text not available from this repository. (Request a copy)Abstract
Case-control studies have shown that regular use of nonsteroidal antiinflammatory drugs (NSAIDs) decreases bladder cancer risk, but few cohort studies have evaluated this association. The authors investigated NSAID use and bladder cancer in 3 large prospective studies (NIH-AARP Diet and Health Study; Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial; and U.S. Radiologic Technologists Study). Frequency of aspirin and nonaspirin NSAID use 1 year prior to baseline was ascertained using self-administered questionnaires. Study-specific hazard ratios and 95% confidence intervals were estimated using Cox regression models and were combined using a fixed-effects meta-analytic model. Data from all studies were aggregated, and aggregated hazard ratios were estimated. The analysis included 508,842 individuals, with 2,489 incident cases of bladder cancer. A reduction in risk was observed for individuals who reported regular use (> 2 times/week) of nonaspirin NSAIDs compared with those who reported no use (hazard ratio (HR) = 0.92, 95% confidence interval (CI): 0.81, 1.04). The risk reduction was limited to nonsmokers (HR = 0.58, 95% CI: 0.41, 0.83) (P-trend = 0.008) (P-interaction = 0.02). No association was observed between regular aspirin use and bladder cancer risk (HR = 1.04, 95% CI: 0.94, 1.15). Results suggest that nonaspirin NSAIDs, but not aspirin, are associated with a reduction in risk of bladder cancer, particularly for nonsmokers.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSITIONAL-CELL CARCINOMA; LOW-DOSE ASPIRIN; URINARY-BLADDER; LARGE COHORT; CYCLOOXYGENASE-2 EXPRESSION; RADIOLOGIC TECHNOLOGISTS; SCREENING TRIAL; RISK; HEALTH; LUNG; anti-inflammatory agents; non-steroidal; aspirin; meta-analysis; urinary bladder neoplasms |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Petra Gürster |
| Date Deposited: | 29 Apr 2020 08:11 |
| Last Modified: | 29 Apr 2020 08:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/21029 |
Actions (login required)
 |
View Item |
