Nemeth, Attila and Laengst, Gernot (2011) Genome organization in and around the nucleolus. TRENDS IN GENETICS, 27 (4). pp. 149-156. ISSN 0168-9525
Full text not available from this repository. (Request a copy)Abstract
The nucleolus is the largest compartment of the cell nucleus and is where ribosomal RNAs (rRNAs) are synthesized, processed and assembled with ribosomal proteins. In addition to rRNA gene clusters that build the core of this subnuclear structure, nucleoli are associated with condensed chromatin. Although the higher order structures of rRNA genes and nucleolus-associated chromatin have been studied for decades, detailed molecular insights into the constituents and organization of the nucleolar genome are only beginning to emerge. Here, we summarize current views on the structural organization of nucleolar DNA and on the targeting and anchoring of chromatin domains to this subnuclear compartment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RIBOSOMAL-RNA GENES; POLYMERASE-I TRANSCRIPTION; REMODELING COMPLEX NORC; TRACT-BINDING PROTEIN; C-MYC; CHROMOSOME CONFORMATION; PROTEOMIC ANALYSIS; HUMAN-CELLS; PERINUCLEOLAR COMPARTMENT; HETEROCHROMATIN FORMATION; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > Prof. Dr. Gernot Längst |
| Depositing User: | Petra Gürster |
| Date Deposited: | 29 Apr 2020 07:04 |
| Last Modified: | 29 Apr 2020 07:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/21043 |
Actions (login required)
 |
View Item |
