Preuss, Ulrich W. and Ridinger, Monika and Rujescu, Dan and Samochowiec, Jerzy and Fehr, Christoph and Wurst, Friedrich M. and Koller, Gabriele and Bondy, Brigitta and Wodarz, Norbert and Debniak, Tadeusz and Grzywacz, Anna and Soyka, Michael and Zill, Peter (2011) Association of ADH4 genetic variants with alcohol dependence risk and related phenotypes: results from a larger multicenter association study. ADDICTION BIOLOGY, 16 (2). pp. 323-333. ISSN 1355-6215, 1369-1600
Full text not available from this repository. (Request a copy)Abstract
Genetic variants of the alcohol-metabolizing enzyme ADH4, located on chromosome 4q22-4q23, have been related to alcohol dependence (AD) risk in previous research. The aim of this association study in a large multicenter sample of alcohol-dependent individuals and controls is to confirm ADH4 single nucleotide polymorphism (SNP) and haplotype association with AD and relevant related phenotypes. One thousand, six hundred and twenty-two (1622) inpatient subjects and 1469 control subjects with DSM-IV. AD from four addiction treatment centres were included. Characteristics of AD and related phenotypes including alcohol withdrawal, Cloninger's type I and II and first ages of drinking, regular drinking and AD onset were obtained using standardized structured interviews. After subjects were genotyped for 2 ADH4 polymorphisms, single SNP case-control and haplotype analyses were conducted. Both variants-rs1800759 and rs1042364-and the A-A and C-G haplotypes were significantly related to AD across samples. Furthermore, associations with AD-related phenotypes and subtypes revealed a potential protective influence of this haplotype. This study confirms the significant relationship of ADH4 variants with AD and related phenotypes. While the rs1800759 and rs1042364 A-A haplotype had a potential protective influence on the risk for several AD-related phenotypes, this effect is rather small compared to functional variants of other alcohol or acetaldehyde-metabolizing enzymes like ALDH2*2 or ADH1B*2.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ISOFORM TPH2 GENE; HAPLOTYPE ANALYSIS; DRUG-DEPENDENCE; FLIP-FLOP; DEHYDROGENASE; POLYMORPHISM; TESTS; DISEQUILIBRIUM; INTERVIEW; ADH4; alcohol dependence; alcohol dependence-related phenotypes; association genetic variants; Cloninger subtypes; ADH4 haplotype analysis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Jun 2020 09:37 |
| Last Modified: | 23 Jun 2020 09:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/21091 |
Actions (login required)
 |
View Item |
