Husser, Oliver and Bodi, Vicente and Sanchis, Juan and Nunez, Julio and Mainar, Luis and Javier Chorro, Francisco and Pilar Lopez-Lereu, Maria and Vicente Monmeneu, Jose and Chaustre, Fabian and Forteza, Maria J. and Trapero, Isabel and Dasi, Francisco and Benet, Isabel and Riegger, Guenter A. J. and Llacer, Angel (2011) White Blood Cell Subtypes after STEMI: Temporal Evolution, Association with Cardiovascular Magnetic Resonance-Derived Infarct Size and Impact on Outcome. INFLAMMATION, 34 (2). pp. 73-84. ISSN 0360-3997,
Full text not available from this repository. (Request a copy)Abstract
The evolution of white blood cells after ST elevation myocardial infarction (STEMI) and their association with infarct size and major adverse cardiac events (MACE) remains unclear. Two hundred eleven patients underwent CMR after STEMI. Infarct mass (grams) was determined. Neutrophil, lymphocyte, and monocyte counts (x1,000 cells/ml) were measured upon arrival and at 12, 24, 48, 72, and 96 h. Patients with large infarctions (3rd tertile a parts per thousand yenaEuro parts per thousand 28.5 g vs. 1st and 2nd tertiles < 28.5 g) showed a larger neutrophil count at 12 h (14.8 +/- 4.8 vs. 11.4 +/- 3.3, p < 0.0001) and an increased monocyte count (maximum at 24 h (0.65[0.50-0.91] vs. 0.55[0.42-0.71], p = 0.004)) but no difference in lymphocyte count. Neutrophil count at 12 h independently predicted large infarctions (OR 1.14, 95%CI [1.04-1.26], p = 0.008). During follow-up (median 504 days), 25 MACE occurred. Neutrophil count at 96 h independently predicted MACE (HR 1.2, 95%CI [1.1-1.4], p = 0.003). Large infarctions show a marked neutrophil peak and an increasing monocyte count. Neutrophil count independently predicts large infarctions and MACE.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACUTE MYOCARDIAL-INFARCTION; ACUTE CORONARY SYNDROMES; MONOCYTOSIS; ANGIOPLASTY; PERFUSION; RECOVERY; COUNT; HEART; myocardial infarction; inflammation; cardiovascular magnetic resonance; prognosis; white blood cells |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Jun 2020 09:38 |
| Last Modified: | 23 Jun 2020 09:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/21093 |
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