Powolny-Budnicka, Iwona and Riemann, Marc and Taenzer, Simone and Schmid, Roland M. and Hehlgans, Thomas and Weih, Falk (2011) ReIA and ReIB Transcription Factors in Distinct Thymocyte Populations Control Lymphotoxin-Dependent Interleukin-17 Production in gamma delta T Cells. IMMUNITY, 34 (3). pp. 364-374. ISSN 1074-7613, 1097-4180
Full text not available from this repository. (Request a copy)Abstract
The NF-kappa B transcription factor regulates numerous immune responses but its contribution to interleukin-17 (IL-17) production by T cells is largely unknown. Here, we report that IL-17, but not interferon-gamma (IFN-gamma), production by gamma delta T cells required the NF-kappa B family members RelA and ReIB as well as the lymphotoxin-beta-receptor (LT beta R). In contrast, LT beta R-NF-kappa B signaling was not involved in the differentiation of conventional alpha beta Th17 cells. Impaired IL-17 production in ReIA- or ReIB-deficient T cells resulted in a diminished innate immune response to Escherichia coli infection. RelA controlled the expression of LT ligands in accessory thymocytes whereas ReIB, acting downstream of LT beta R, was required for the expression of ROR gamma t and ROR alpha 4 transcription factors and the differentiation of thymic precursors into gamma delta T17 cells. Thus, RelA and ReIB within different thymocyte subpopulations cooperate in the regulation of IL-17 production by gamma delta T cells and contribute to the host's ability to fight bacterial infections.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ESCHERICHIA-COLI INFECTION; CUTTING EDGE; PROINFLAMMATORY IL-17(+); DIFFERENTIAL REGULATION; GENE-EXPRESSION; RECEPTOR; RELA; PATHWAY; MEMBER; ALPHA; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Immunologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Jun 2020 04:51 |
| Last Modified: | 24 Jun 2020 04:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/21101 |
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