Lippert, Elisabeth and Klebl, Frank H. and Schweller, Florian and Ott, Claudia and Gelbmann, Cornelia M. and Schoelmerich, Juergen and Endlicher, Esther and Kullmann, Frank (2011) Fibrin glue in the endoscopic treatment of fistulae and anastomotic leakages of the gastrointestinal tract. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 26 (3). pp. 303-311. ISSN 0179-1958, 1432-1262
Full text not available from this repository. (Request a copy)Abstract
Fistulae or leakages of anastomotic junctions of the gastrointestinal tract used to be an indication for surgery. However, patients often are severely ill and endoscopic therapeutic options have been suggested to avoid surgical intervention. This is a retrospective analysis of fibrin glue application in the treatment of gastrointestinal fistulae or anastomotic leakages. The aim of this study was to investigate the value of fibrin glue in the treatment of gastrointestinal fistulae and leakages. From September 1996 to November 2002, 52 patients with gastrointestinal fistulae or insufficiencies have been treated endoscopically including the use of fibrin glue (Tissucol Duo SA (R), Baxter, Unterschleissheim, Germany). Clinical data comprising concomitant therapies and results were analysed by chart review. Twenty-six lesions were located in the oesophagus or gastroesophageal junction, 4 in the stomach, 7 in the small intestine, 13 colorectal and 2 in the pancreas. The duration of treatment ranged from 12 to 1,765 days. Two to 81 ml fibrin glue (median 8.5) was used in 1-40 sessions (median 4). All patients received antibiotics; additional endoscopic options were frequently applied. Endoscopic therapy cured 55.7% patients (n = 29); 36.5% (n = 19) were cured with fibrin glue as sole endoscopic option. In 23.1% (n = 12), surgical intervention became necessary. Patients without major infectious complications tended to have a higher cure rate without surgery (87.5% vs. 50%). Eleven patients died (21.1%). Endoscopic therapy is a valuable option in the treatment of fistulae and anastomotic insufficiencies of the gastrointestinal tract. It usually is applied repeatedly. Fibrin glue is a mainstay of this procedure. Major infectious complications seem to define a subgroup of patients with poorer outcome.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COMPLEX ANAL FISTULAS; RISK-FACTORS; RECTAL-CANCER; ANTERIOR RESECTION; MULTIVARIATE-ANALYSIS; IN-ANO; SURGERY; SEALANT; INJECTION; LEAKS; Fibrin glue; Fistulae; Endoscopic treatment |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Jun 2020 12:40 |
| Last Modified: | 25 Jun 2020 12:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/21212 |
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