Boehm, Francine and Schmid, Dagmar and Denzinger, Stefan and Wieland, Wolf F. and Richter, Elmar (2011) DNA adducts of ortho-toluidine in human bladder. BIOMARKERS, 16 (2). pp. 120-128. ISSN 1354-750X, 1366-5804
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Methods: Determination of 4-ABP and o-toluidine-releasing DNA adducts in epithelial and submucosal bladder tissues of sudden death victims (SDV: n == 46), and bladder tumours (n == 12) by gas chromatography/mass spectrometry. Results: Above background, 4 and 11 of 12 tumour samples contained adducts of 4-ABP (0.057 +/-+/- 0.125 fmol/mu A mu g DNA) and o-toluidine (8.72 +/-+/- 4.49 fmol/mu A mu g DNA), respectively. Lower adduct levels were present in both epithelial and submucosal bladder tissues of SDV (4-ABP: 0.011 +/-+/- 0.022 and 0.019 +/-+/- 0.047 fmol/mu A mu g DNA; o-toluidine: 0.24 +/-+/- 0.63 and 0.27 +/-+/- 0.70 fmol/mu A mu g DNA). Conclusion: Detection of o-toluidine-releasing DNA adducts support the carcinogenicity of o-toluidine in the human bladder.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TOBACCO-SPECIFIC NITROSAMINES; CARCINOGENIC AROMATIC-AMINES; METHYLATED ANILINES PRESENT; HEMOGLOBIN ADDUCTS; 4-AMINOBIPHENYL-DNA ADDUCTS; MASS-SPECTROMETRY; CIGARETTE-SMOKE; URINARY-BLADDER; O-ANISIDINE; CANCER; 4-aminobiphenyl; carcinogenicity; gas chromatography; mass spectrometry; smoking |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Jun 2020 07:17 |
| Last Modified: | 25 Jun 2020 07:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/21220 |
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