Singer, Katrin and Gottfried, Eva and Kreutz, Marina and Mackensen, Andreas (2011) Suppression of T-cell responses by tumor metabolites. CANCER IMMUNOLOGY IMMUNOTHERAPY, 60 (3). pp. 425-431. ISSN 0340-7004, 1432-0851
Full text not available from this repository. (Request a copy)Abstract
Tumor cells have developed multiple mechanisms to escape T-cell-mediated immune recognition. Recent work has revealed that the altered tumor metabolism depletes essential nutrients or leads to the accumulation of immunosuppressive metabolites in the tumor microenvironment. In this review, we discuss the suppressive activity of some metabolic key players, which are upregulated in human tumor cells, including indolamine-2,3-dioxygenase (IDO), arginase, inducible nitric oxide synthetase (iNOS), and lactate dehydrogenase (LDH)-A, on the adaptive immune system. A better understanding of the impact of metabolic alterations of tumor cells on effector T-cell functions could lead to new therapeutic strategies to improve the efficacy of cancer immunotherapy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; ACUTE LYMPHOBLASTIC-LEUKEMIA; L-ARGININE METABOLISM; INDOLEAMINE 2,3-DIOXYGENASE; GLUCOSE-METABOLISM; COLORECTAL-CANCER; PROGNOSTIC VALUE; LACTIC-ACID; ARGINASE-I; IFN-GAMMA; Tumor metabolism; Immune escape; Cytotoxic T cells; Lactic acid |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 28 Apr 2020 10:13 |
| Last Modified: | 28 Apr 2020 10:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/21232 |
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