Boeger, Carsten A. and Chen, Ming-Huei and Tin, Adrienne and Olden, Matthias and Koettgen, Anna and de Boer, Ian H. and Fuchsberger, Christian and O'Seaghdha, Conall M. and Pattaro, Cristian and Teumer, Alexander and Liu, Ching-Ti and Glazer, Nicole L. and Li, Man and O'Conne, Jeffrey R. and Tanaka, Toshiko and Peralta, Carmen A. and Kutalik, Zoltan and Luan, Jian'an and Zhao, Jing Hua and Hwang, Shih-Jen and Akylbekova, Ermeg and Kramer, Holly and van der Harst, Pim and Smith, Albert V. and Lohman, Kurt and de Andrade, Mariza and Hayward, Caroline and Kollerits, Barbara and Toenjes, Anke and Aspelund, Thor and Ingelsson, Erik and Eiriksdottir, Gudny and Launer, Lenore J. and Harris, Tamara B. and Shuldiner, Alan R. and Mitchell, Braxton D. and Arking, Dan E. and Franceschini, Nora and Boerwinkle, Eric and Egan, Josephine and Hernandez, Dena and Reilly, Muredach and Townsend, Raymond R. and Lumley, Thomas and Siscovick, David S. and Psaty, Bruce M. and Kestenbaum, Bryan and Haritunians, Talin and Bergmann, Sven and Vollenweider, Peter and Waeber, Gerard and Mooser, Vincent and Waterworth, Dawn and Johnson, Andrew D. and Florez, Jose C. and Meigs, James B. and Lu, Xiaoning and Turner, Stephen T. and Atkinson, Elizabeth J. and Leak, Tennille S. and Aasarod, Knut and Skorpen, Frank and Syvaenen, Ann-Christine and Illig, Thomas and Baumert, Jens and Koenig, Wolfgang and Kraemer, Bernhard K. and Devuyst, Olivier and Mychaleckyj, Josyf C. and Minelli, Cosetta and Bakker, Stephan J. L. and Kedenko, Lyudmyla and Paulweber, Bernhard and Coassin, Stefan and Endlich, Karlhans and Kroemer, Heyo K. and Biffar, Reiner and Stracke, Sylvia and Voelzke, Henry and Stumvol, Michael and Maegi, Reedik and Campbell, Harry and Vitart, Veronique and Hastie, Nicholas D. and Gudnason, Vilmundur and Kardia, Sharon L. R. and Liu, Yongmei and Polasek, Ozren and Curhan, Gary and Kronenberg, Florian and Prokopenko, Inga and Rudan, Igor and Aernloev, Johan and Hallan, Stein and Navis, Gerjan and Parsa, Afshin and Ferrucci, Luigi and Coresh, Josef and Shlipak, Michael G. and Bul, Shelley B. and Paterson, Andrew D. and Wichmann, H. -Erich and Wareham, Nicholas J. and Loos, Ruth J. F. and Rotter, Jerome I. and Pramstaller, Peter P. and Cupples, L. Adrienne and Beckmann, Jacques S. and Yang, Qiong and Heid, Iris M. and Rettig, Rainer and Dreisbach, Albert W. and Bochud, Murielle and Fox, Caroline S. and Kao, W. H. L. (2011) CUBN Is a Gene Locus for Albuminuria. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 22 (3). pp. 555-570. ISSN 1046-6673, 1533-3450
Full text not available from this repository. (Request a copy)Abstract
Identification of genetic risk factors for albuminuria may alter strategies for early prevention of CKD progression, particularly among patients with diabetes. Little is known about the influence of common genetic variants on albuminuria in both general and diabetic populations. We performed a meta-analysis of data from 63,153 individuals of European ancestry with genotype information from genome-wide association studies (CKDGen Consortium) and from a large candidate gene study (CARe Consortium) to identify susceptibility loci for the quantitative trait urinary albumin-to-creatinine ratio (UACR) and the clinical diagnosis microalbuminuria. We identified an association between a missense variant (I2984V) in the CUBN gene, which encodes cubilin, and both UACR (P = 1.1 x 10(-11)) and microalbuminuria (P = 0.001). We observed similar associations among 6981 African Americans in the CARe Consortium. The associations between this variant and both UACR and microalbuminuria were significant in individuals of European ancestry regardless of diabetes status. Finally, this variant associated with a 41% increased risk for the development of persistent microalbuminuria during 20 years of follow-up among 1304 participants with type 1 diabetes in the prospective DCCT/EDIC Study. In summary, we identified a missense CUBN variant that associates with levels of albuminuria in both the general population and in individuals with diabetes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENOME-WIDE ASSOCIATION; CHRONIC KIDNEY-DISEASE; LOW-GRADE ALBUMINURIA; RENAL-FUNCTION; ALBUMIN/CREATININE RATIO; DIABETIC-NEPHROPATHY; LINKAGE ANALYSIS; PROXIMAL TUBULE; RISK-FACTORS; DESIGN; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Jun 2020 09:01 |
| Last Modified: | 25 Jun 2020 09:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/21246 |
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