Hafner, Christian and Kamenisch, York and Landthaler, Michael and Berneburg, Mark (2011) Distinct profile of the mitochondrial DNA common deletion in benign skin lesions. EXPERIMENTAL DERMATOLOGY, 20 (2). pp. 151-153. ISSN 0906-6705, 1600-0625
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Mutations of mitochondrial (mt) DNA, particularly the 4977 bp long common deletion, are increased in aging tissues and preferentially found in chronologically and photoaged skin. Mutations of human mitochondrial DNA (mtDNA) have also been identified in malignant tumors of the skin and of other organs. However, benign skin lesions have not yet been investigated. We analyzed the frequency of the common deletion in 27 benign skin lesions [8 seborrheic keratoses (SK), 5 epidermal nevi (EN), 14 solar lentigos (SL)] by quantitative real-time PCR, because SK and especially SL have been related to (photo)aged skin. All SK and four of five EN displayed reduced common deletion levels compared with adjacent normal skin. In contrast, 50% of SL revealed a higher percentage of the common deletion than the adjacent normal skin, and some SL showed very high absolute common deletion levels up to 14% of total mtDNA. Our results show that the amount of the common deletion is significantly different in benign skin lesions and raise further questions regarding the pathogenesis of SL and its possible role as a precursor lesion of SK.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | T-CELLS; IL-18; GAMMA; common deletion; epidermal nevus; mitochondrial DNA; seborrheic keratosis; solar lentigo |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Aug 2023 10:05 |
| Last Modified: | 02 Aug 2023 10:05 |
| URI: | https://pred.uni-regensburg.de/id/eprint/21307 |
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