Kollins, D. and Stoelcker, B. and Hoffmann, U. and Bergler, T. and Reinhold, S. and Banas, M. C. and Ruemmele, P. and Farkas, S. and Kraemer, B. K. and Banas, B. (2011) FOXP3+ regulatory T-cells in renal allografts: correlation with long-term graft function and acute rejection. CLINICAL NEPHROLOGY, 75 (2). pp. 91-100. ISSN 0301-0430,
Full text not available from this repository. (Request a copy)Abstract
Background: The interpretation of a cellular infiltrate as cytotoxic or tolerogen represents an unsolved challenge in current transplantation. The so-called regulatory CD4+ CD25+ T-cells which express the FOXP3 gene have received increasing interest with respect to this question. The existing studies concerning the role of FOXP3+ Tregs for transplant tolerance yielded contradictory results. Methods: We examined the numbers of the FOXP3+ Tregs in two groups of renal allograft biopsies both showing cellular infiltration, but either without (n = 29) or with signs of acute cellular rejection (n = 26), by means of immunofluorescence and correlated the amount of FOXP3+ Tregs to renal function at the time of biopsy and after 1 and 2 years of follow up. Results: The number of FOXP3+ Tregs within infiltrates in non-rejecting biopsies did not correlate with renal function after I and 2 years. There were no significant differences in the numbers of FOXP3+ Tregs between biopsies with or without borderline infiltrates. Increased numbers of FOXP3+ Tregs were not associated with an ameliorated severity of graft rejection and did not correlate with outcome after the rejection episode and renal function after 1 and 2 years. Conclusions: The identification of the FOXP3+ regulatory cells within the allograft cannot be considered as an appropriate marker for the interpretation of infiltrates as cytotoxic or tolerogenic or as a prognostic marker for later transplant function.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSPLANTATION TOLERANCE; BORDERLINE CHANGE; MESSENGER-RNA; RECIPIENTS; BIOPSIES; PROTEIN; transplantation; FOXP3 gene; FOXP3+Tregs; graft function; renal allograft rejection; immunofluorescence; prognostic marker |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Jun 2020 10:52 |
| Last Modified: | 26 Jun 2020 10:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/21341 |
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