Klein, Christoph A. (2011) Framework models of tumor dormancy from patient-derived observations. CURRENT OPINION IN GENETICS & DEVELOPMENT, 21 (1). pp. 42-49. ISSN 0959-437X
Full text not available from this repository. (Request a copy)Abstract
Unusually long latency periods between the treatment of primary tumors and metastatic recurrences are commonly thought to prove the existence and relevance of clinical tumor dormancy. However, careful consideration of disease courses and cancer growth rates leads to the conclusion that clinical dormancy may be everything from non-existent to much more frequent than originally thought. On the other hand, cellular dormancy defined as a non-productive state of disseminated tumor cells is very frequent, while homeostatic mechanisms such as angiogenic and immunological control contribute to the chronicity of cancer. This review attempts to provide a conceptual framework for the study of dormancy, which may guide clinical and experimental research.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CARDIOTHORACIC TRANSPLANT RECIPIENTS; ENDOPLASMIC-RETICULUM KINASE; BONE-MARROW NICHE; BREAST-CANCER; MALIGNANT-MELANOMA; IN-VIVO; LATE RECURRENCE; METASTATIC OUTGROWTH; EXTRACELLULAR-MATRIX; CELLULAR QUIESCENCE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 28 Apr 2020 07:43 |
| Last Modified: | 28 Apr 2020 07:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/21343 |
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