Wiest, Reiner and Weigert, Johanna and Wanninger, Josef and Neumeier, Markus and Bauer, Sabrina and Schmidhofer, Sandra and Farkas, Stefan and Scherer, Marcus N. and Schaeffler, Andreas and Schoelmerich, Juergen and Buechler, Christa (2011) Impaired hepatic removal of interleukin-6 in patients with liver cirrhosis. CYTOKINE, 53 (2). pp. 178-183. ISSN 1043-4666, 1096-0023
Full text not available from this repository. (Request a copy)Abstract
Systemic concentrations of interleukin-6 (IL-6) are elevated in patients with liver cirrhosis, and impaired hepatic uptake of IL-6 was suggested to contribute to higher levels in these patients. To test this hypothesis IL-6 was measured in portal venous serum (PVS), hepatic venous serum (HVS) and systemic venous serum (SVS) of 41 patients with liver cirrhosis and four patients with normal liver function. IL-6 was higher in PVS than HVS of all blood donors and about 43% of portal vein derived IL-6 was extracted by the healthy liver, and 6.3% by the cirrhotic liver demonstrating markedly impaired removal of IL-6 by the latter. Whereas in patients with CHILD-PUGH stage A IL-6 in HVS was almost 25% lower than in PVS, in patients with CHILD-PUGH stage C IL-6 was similarly abundant in the two blood compartments. Ascites is a common complication in cirrhotic patients and was associated with higher IL-6 levels in all blood compartments without significant differences in hepatic excretion. Hepatic venous pressure gradient did not correlate with the degree of hepatic IL-6 removal excluding hepatic shunting as the principal cause of impaired IL-6 uptake. Furthermore, patients with alcoholic liver cirrhosis had higher IL-6 in all blood compartments than patients with cryptogenic liver cirrhosis. Aetiology of liver cirrhosis did not affect hepatic removal rate indicating higher IL-6 synthesis in patients with alcoholic liver cirrhosis. In summary, the current data provide evidence that impaired hepatic removal of IL-6 is explained by hepatic shunting and liver dysfunction in patients with liver cirrhosis partly explaining higher systemic levels. (C) 2010 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NECROSIS-FACTOR-ALPHA; PERITONEAL-CAVITY; BILIARY-CIRRHOSIS; IN-VIVO; HUMANS; ASCITES; DISEASE; MICE; INFLAMMATION; HEPATOCYTES; Interleukin-6; Liver cirrhosis; Portal vein; Hepatic vein |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Jun 2020 10:54 |
| Last Modified: | 26 Jun 2020 10:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/21344 |
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