Schweda, Frank and Kurtz, A. (2011) Regulation of Renin Release by Local and Systemic Factors. In: UNSPECIFIED Reviews of Physiology Biochemistry and Pharmacology,, 161 . SPRINGER-VERLAG BERLIN, BERLIN, pp. 1-44. ISBN 978-3-540-87631-1; 978-3-540-87628-1
Full text not available from this repository. (Request a copy)Abstract
The renin-angiotensin system (RAS) is critically involved in the regulation of the salt and volume status of the body and blood pressure. The activity of the RAS is controlled by the protease renin, which is released from the renal juxtaglomerular epithelioid cells into the circulation. Renin release is regulated in negative feedback-loops by blood pressure, salt intake, and angiotensin II. Moreover, sympathetic nerves and renal autacoids such as prostaglandins and nitric oxide stimulate renin secretion. Despite numerous studies there remained substantial gaps in the understanding of the control of renin release at the organ or cellular level. Some of these gaps have been closed in the last years by means of gene-targeted mice and advanced imaging and electrophysiological methods. In our review, we discuss these recent advances together with the relevant previous literature on the regulation of renin release.
| Item Type: | Book Section |
|---|---|
| Uncontrolled Keywords: | ATRIAL-NATRIURETIC-PEPTIDE; NITRIC-OXIDE-SYNTHASE; MACULA DENSA CYCLOOXYGENASE-2; GENE-RELATED PEPTIDE; TUBULOGLOMERULAR FEEDBACK-REGULATION; VASOACTIVE INTESTINAL POLYPEPTIDE; GLOMERULAR-FILTRATION-RATE; RAT JUXTAGLOMERULAR CELLS; BLOOD-PRESSURE REGULATION; DEPENDENT PROTEIN-KINASE; |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Frank Schweda |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Jul 2020 10:08 |
| Last Modified: | 22 Jul 2020 10:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/21412 |
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